A kind of medicine for treating hypertension and preparation method thereof
A high blood pressure and drug technology, which is applied in the field of drugs for the treatment of high blood pressure and its preparation, can solve the problems of large individual differences in drug absorption and metabolism, low compliance, and low treatment efficiency, so as to reduce the incidence of cardiovascular diseases and Mortality rate, improvement of treatment rate and control rate, significant effect of systolic blood pressure decrease
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Embodiment 1
[0025] The drug for treating hypertension in this embodiment is in the dosage form of a sustained-release capsule, which is mainly prepared from the following raw materials in parts by weight: 100 parts of nifedipine and 50 parts of metoprolol.
[0026] The preparation method of the medicine of the present embodiment for the treatment of hypertension, the specific operation steps are:
[0027] 1) Measure nifedipine according to the formula, and prepare nifedipine sustained-release pellets with clinically acceptable auxiliary materials; measure metoprolol according to the formula, and prepare metoprolol sustained-release microspheres with clinically acceptable auxiliary materials. pill;
[0028] 2) Mix the nifedipine sustained-release pellets and metoprolol sustained-release pellets prepared in step 1) to form capsules, and the preparation is complete.
Embodiment 2
[0030] The drug for treating hypertension in this embodiment is in the dosage form of a sustained-release capsule, which is mainly prepared from the following raw materials in parts by weight: 180 parts of nifedipine and 90 parts of metoprolol.
[0031] The preparation method of the medicine of the present embodiment for the treatment of hypertension, the specific operation steps are:
[0032] 1) Measure nifedipine according to the formula, and prepare nifedipine sustained-release pellets with clinically acceptable auxiliary materials; measure metoprolol according to the formula, and prepare metoprolol sustained-release microspheres with clinically acceptable auxiliary materials. pill;
[0033] 2) Mix the nifedipine sustained-release pellets and metoprolol sustained-release pellets prepared in step 1) to form capsules, and the preparation is complete.
Embodiment 3
[0035] The medicine for treating hypertension in this embodiment is in the dosage form of sustained-release capsules, and about 100 mg of each capsule contains: 5 mg of nifedipine and 2.5 mg of metoprolol.
[0036] The preparation method of the medicine of the present embodiment for the treatment of hypertension, the specific operation steps are:
[0037] 1) Measure nifedipine according to the formula, and prepare nifedipine sustained-release pellets with clinically acceptable auxiliary materials; measure metoprolol according to the formula, and prepare metoprolol sustained-release microspheres with clinically acceptable auxiliary materials. pill;
[0038] 2) Mix the nifedipine sustained-release pellets and metoprolol sustained-release pellets prepared in step 1) to form capsules, and the preparation is complete.
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