A method for rapid detection of isothiazolinone compounds in water-based adhesives for cigarettes
A technology for isothiazolinone and tobacco water-based glue, which is applied in the field of chemical detection and achieves the effects of simple pretreatment, fast analysis speed and high sensitivity
Active Publication Date: 2020-11-20
CHINA TOBACCO GUIZHOU IND
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Problems solved by technology
The reported detection methods of isothiazolinone compounds in water-based adhesives include high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry, but there is no report on ultra-high performance liquid chromatography
Method used
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Embodiment 1
[0044] 1) Accurately weigh 0.3g of 8 different types of tobacco water-based glue samples into a 50mL Erlenmeyer flask with a stopper, first add 10mL of ultrapure water and shake slightly to disperse the water-based glue evenly, then add 10mL of methanol to mix well, and then ultrasonicate for 30min ;
[0045] 2) Transfer to a 50mL centrifuge tube, centrifuge at 9000r / min for 5min, take 2mL of the supernatant, blow it with nitrogen and concentrate it to 1mL (if it is less than 1mL, add ultrapure water to make up to 1mL) and pass through a 0.22μm water phase filter membrane in the chromatography bottle, to be analyzed;
[0046] 3) Quantitative analysis was carried out by ultra-high performance liquid chromatography-diode array (UPLC-PDA), and the detection results are shown in Table 4.
[0047] Among them, the UPLC-PDA conditions are as follows:
[0048] Chromatographic conditions: analytical column: Waters ACQUITY UPLC HSS T3 (2.1×50mm, 1.7μm); column temperature: 35℃; inject...
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The invention discloses a method for rapid determination of isothiazolinone compounds in a water-based adhesive for cigarettes. The method comprises the following steps: adding an extraction agent into the water-based adhesive for cigarettes, wherein a volume mass ratio of the extraction agent to a water-based adhesive sample is 5-40 mL: 0.3 g; then carrying out ultrasonic extraction for 5 to 45 min so as to obtain extract liquor; subjecting the obtained extract liquor to centrifugation, taking supernatant and introducing nitrogen into the supernatant so as to obtain concentrated supernatant; allowing the concentrated supernatant to pass through a filter membrane so as to obtain a to-be-detected solution; and carrying out quantitative analysis on the isothiazolinone compounds in the to-be-detected solution by using ultrahigh performance liquid chromatography-diode array. The method provided by the invention can carry out simultaneous analysis and detection on at least three isothiazolinone compounds in the water-based adhesive for cigarettes; the method is simple in treatment and fast in analysis speed; detection results are good in repeatability and high in sensitivity; and the method is applicable to determination of three isothiazolinone compounds in the water-based adhesive for cigarettes or in other complex matrixes.
Description
technical field [0001] The invention relates to the technical field of chemical detection, and more specifically relates to a method for rapidly detecting isothiazolinone compounds in water-based adhesives for tobacco use. Background technique [0002] Water-based glue is a water-containing latex formed by emulsion polymerization, which is easily attacked by microorganisms, and the addition of isothiazolinone can play a role in sterilization and antisepsis. However, studies have found that isothiazolinone compounds exposed to the environment will pose health risks, such as methylisothiazolinone, which has certain cytotoxicity and neurotoxicity, and has allergic reactions when it comes into contact with the skin. At home and abroad, there are strict controls on the dosage, residue and specific migration of isothiazolinone fungicides in the fields of toys, food, cosmetics, etc., such as the EU toy safety standard EN71-9-2005 (for MI, CMI and The limits of BIT are 10, 10 and 5 ...
Claims
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IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 姬厚伟刘剑彭黔荣董睿张丽王芳
Owner CHINA TOBACCO GUIZHOU IND