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Silver-poly dopamine-graphene-modified electrochemical sensor and preparation method thereof

A polydopamine and graphene technology, applied in the field of chemical analysis, can solve the problems of time-consuming and multi-sample processing, complex and expensive instruments, etc., and achieve the effects of no impact on physical health, environmental friendliness, and simple instruments

Inactive Publication Date: 2013-02-06
XINYANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods either use complex and expensive instruments, require dedicated personnel to operate, or require time-consuming sample processing

Method used

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  • Silver-poly dopamine-graphene-modified electrochemical sensor and preparation method thereof
  • Silver-poly dopamine-graphene-modified electrochemical sensor and preparation method thereof
  • Silver-poly dopamine-graphene-modified electrochemical sensor and preparation method thereof

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Embodiment 1

[0039] Such as figure 1 As shown, the silver-polydopamine-graphene modified electrochemical sensor of the present invention includes a glassy carbon substrate 1, electrode leads 3, and an insulating layer 4, and the surface of the glassy carbon substrate 1 is coated with a silver-polydopamine-graphene composite film 2. Silver-polydopamine-graphene composite film 2 was obtained by ultrasonically dispersing 0.1-1 mg of silver-polydopamine-graphene composite in 1-10 mL of DMF.

[0040] The preparation method of the electrochemical sensor modified by above-mentioned silver-polydopamine-graphene comprises the following steps:

[0041] (1) Glassy carbon electrode pretreatment;

[0042] (2) Add the silver-polydopamine-graphene compound into dimethylformamide (DMF), and disperse it uniformly by ultrasonic to obtain the silver-polydopamine-graphene dispersion;

[0043] (3) The silver-polydopamine-graphene dispersion liquid was drop-coated on the surface of the pretreated glassy carb...

Embodiment 2

[0048] The preparation of silver-polydopamine-graphene composite comprises the following steps:

[0049](1) Ultrasonic disperse 100 mg of graphene in 100 mL of twice distilled water, then add 200 mg of dopamine and 120 mg of trishydroxymethylaminomethane, ultrasonicate the above mixture for 1 min in an ice-water bath, and stir at room temperature After 20 h, the obtained product was filtered, washed, and then dried in a vacuum oven at 60 °C to obtain a polydopamine-graphene composite.

[0050] (2) Add 25 mg polydopamine-graphene to 25 mL (1×10 -3 mol / L) AgNO 3 In aqueous solution, stirred at room temperature for 2 h, then the resulting mixture was filtered, washed, and dried in a vacuum oven at 60 °C to obtain a silver-polydopamine-graphene nanocomposite.

Embodiment 3

[0052] Transmission electron microscopy (TEM) of the silver-polydopamine-graphene nanocomposite.

[0053] figure 2 TEM image of graphene, graphene presents a typical sheet structure; image 3 For the TEM of silver-polydopamine-graphene nanocomposite, the graphene surface has Ag nano-attachment.

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Abstract

The invention discloses a silver-poly dopamine-graphene-composite-modified electrochemical sensor which is mainly characterized in that a silver-poly dopamine-graphene composite membrane is coated on the surface of a glassy carbon electrode. A preparation method of the silver-poly dopamine-graphene-composite-modified electrochemical sensor includes: adding silver-poly dopamine-graphene into dimethylformamide for uniform dispersing so that silver-poly dopamine-graphene dispersion liquid is obtained, then coating the dispersion liquid on the surface of the glassy carbon electrode, and evaporating solvent to obtain the needed sensor. A silver-poly dopamine-graphene composite is prepared only by mixing reactants and stirring at the room temperature. The preparation method is simple, mild in reaction conditions and low in cost. The prepared electrochemical sensor has the advantages of high sensitivity, low detection limit and the like, and is capable of achieving rapid sensitivity determination of guanine and adenine, simple to operate, green and environment-friendly.

Description

technical field [0001] The invention belongs to the field of chemical analysis, in particular to a silver-polydopamine-graphene modified electrochemical sensor and a preparation method thereof. Background technique [0002] Guanine and adenine are important alkaloids and important components of DNA, which play important fundamental roles in the process of life. They play a significant role in regulating coronary artery and cerebral circulation, controlling blood flow, preventing arrhythmia, releasing neurotransmitters and regulating the activity of adenylate cyclase. By detecting the changes of guanine and adenine in the body, the degree of DNA damage can be predicted and the occurrence of certain diseases can be indicated. Therefore, it is of great significance for the determination of guanine and adenine. [0003] At present, the main methods for detecting guanine and adenine include high performance liquid chromatography, capillary electrophoresis, photometry, chemilumi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 刘彦明黄克靖吴莹莹
Owner XINYANG NORMAL UNIVERSITY
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