Nano drug memory, its preparation method and application

A nano-medicine and memory technology, applied in the field of biomedicine, can solve problems such as difficult acceptance by patients and implementation difficulties, and achieve the effect of stability

Active Publication Date: 2019-04-05
JIAXING QINGZHUN MEDI-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Frequent small-dose administration can adjust the blood drug concentration and avoid the above phenomenon, but it is often difficult for patients to accept it, and there are many difficulties in implementation. Therefore, the preparation of sustained-release long-acting drugs that can slowly release drug components is often very necessary in treatment. of

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  • Nano drug memory, its preparation method and application
  • Nano drug memory, its preparation method and application
  • Nano drug memory, its preparation method and application

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Embodiment Construction

[0029] In order to describe the technical content of the present invention more clearly, further description will be given below in conjunction with specific embodiments.

[0030] The nano-drug storage, its preparation method and its application are mainly characterized in that the nano-drug storage is composed of a tri-block polymer copolymer, which is self-assembled in water by interacting with drugs, wherein the tri-block The first segment of the polymer copolymer is polylactic acid-glycolic acid 6000Da, the second segment is polyethylene glycol 3000Da, and the third segment is polytolueneboronic acid 15000Da. The medicine is lanosterol. The nano-drug storage device is composed of a triblock polymer copolymer polytoluene boric acid-polyethylene glycol-polylactic acid-glycolic acid, and forms a nano-drug storage device in a self-assembled manner by neutralizing drug molecules in water. Among them, the first segment of the block polymer copolymer is polylactic acid-glycolic ...

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Abstract

The invention relates to a nano medicament storage as well as a preparation method and application thereof. The nano medicament storage is formed by self-assembly of a three-block high molecular copolymer and medicaments in water, wherein the first block of the three-block high molecular copolymer is polylactic acid-glycolic acid 6000Da, the second block is polyethylene glycol 3000Da, and the third block is polytoluene boric acid 15000Da. According to the nano medicament storage, the preparation method and application thereof, the adopted raw materials are extremely good in biocompatibility, pass American FDA authentication, can be self-degraded in organisms, are widely applied in the fields of food, medicaments and cosmetics, can be degraded into human inherent metabolites in vivo and excreted along with body fluid, are absolutely safe and do not have toxic or side effect. The nano medicament storage is widely applicable to medicaments, and is controllable in mold size and shape, medicament slow-release time and in-vivo degradation speed.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to nano-medicine, specifically to a nano-medicine storage, its preparation method and its application. Background technique [0002] Nano-scale drug carrier is a sub-particle drug carrier delivery system belonging to the category of nano-scale microcosm. Encapsulating drugs in sub-particles can adjust the release rate, increase the permeability of biofilms, change the distribution in the body, and improve bioavailability, etc. Nanoparticles (NPs), also known as nanoparticles, are solid colloidal particles with a size between 10 and 1000 nm, generally composed of natural polymers or synthetic polymers, and can be used as carriers for conduction or delivery of drugs. Due to differences in materials and preparation processes, nanospheres and nanocapsules can be formed, which are collectively referred to as nanoparticles. In the block copolymer molecular chain, the mutual thermodyna...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/51A61K47/34A61K31/575A61K9/06A61K47/36A61P27/02
CPCA61K9/0002A61K9/0048A61K9/06A61K9/5146A61K9/5192A61K31/575A61K47/36
Inventor陈麒先刘俊
OwnerJIAXING QINGZHUN MEDI-TECH CO LTD