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Application of loganin in preparation of medicine for improving sleep

A technology for improving sleep and loganin, applied in the field of medicine, can solve problems that have not been seen, have not seen any research, and improve sleep

Active Publication Date: 2019-05-10
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has not been any research on the pharmacological effects and clinical applications of loganin in improving or treating sleep disorders, prolonging sleep time, etc.
[0006] At present, the Chinese invention patents about loganin can only be seen in the preparation method (CN104447910A), the content determination method (CN103808811A) and the preparation of drugs for treating diabetes (CN103110651A), and there is no report on improving sleep.

Method used

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  • Application of loganin in preparation of medicine for improving sleep
  • Application of loganin in preparation of medicine for improving sleep
  • Application of loganin in preparation of medicine for improving sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Effect of loganin on sleep time and sleep latency of mice induced by suprathreshold dose of pentobarbital sodium

[0044] Male ICR mice with a body weight of 20-24 g (provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal qualification certificate number: SCXK (Beijing) 2012-0001) were randomly divided into blank solvent control groups according to body weight , Estazolam (Estazolam, produced by Shandong Xinyi Co., Ltd., batch number: 150910) 1.375mg / kg group, loganin 5mg / kg group, 20mg / kg group and 50mg / kg group, 15 in every group, fed Stomach administration, and record the administration time, 20min after intraperitoneal injection of suprathreshold dose of pentobarbital sodium (45mg / kg). The disappearance of righting reflex was taken as the time of falling asleep, and the recovery of righting reflex was taken as the time of waking up, and the sleep latency and sleep duration of the mice were recorded.

[0045] The experimental re...

Embodiment 2

[0049] Example 2 Effect of loganin on sleep-onset rate of mice injected intraperitoneally with subthreshold dose of pentobarbital sodium

[0050] Male ICR mice weighing 20-24 g were randomly divided into blank solvent control group, estazolam 1.375 mg / kg group, loganin 5 mg / kg group, 20 mg / kg group and 50 mg / kg group according to body weight. Group, 20 mice in each group, administered by intragastric administration, and recorded the administration time, intraperitoneally injected a subthreshold dose of pentobarbital sodium (22mg / kg) after 20min, observed and recorded the sleeping situation of the mice.

[0051] The experimental results are as shown in Table 2. Loganin 20 and 50 mg / kg orally administered can significantly increase the number of mice falling asleep caused by subthreshold dose pentobarbital sodium (P<0.05). The experimental results show that the horses Qiangside and subthreshold dose of pentobarbital sodium have a synergistic hypnotic effect.

[0052] Table 2 The ...

Embodiment 3

[0055] Example 3 Intervention of loganin on PCPA-induced insomnia model

[0056] Male ICR mice with a body weight of 20-24 g were randomly divided into blank solvent control group, PCPA (p-chlorophenylalanine, purchased from Sigma, 350 mg / kg, i.p.) group, loganin (50 mg / kg, i.g.) group and PCPA (350mg / kg, i.p.)+loganin (50mg / kg, i.g.) group. The administration method is firstly to inject PCPA into the abdominal cavity continuously for 3 days to establish the insomnia model in mice. After 1 hour of intraperitoneal injection of PCPA on the 3rd day, loganin is administered into the stomach, and 20 minutes later, the upper threshold dose of pentobarbital sodium is injected intraperitoneally to reverse the insomnia. The time of falling asleep was defined as the disappearance of the righting reflex, and the time of waking up when the righting reflex returned. The sleep latency and sleep duration of the mice were recorded.

[0057] The experimental results are shown in Table 3. Log...

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Abstract

Belonging to the field of compound drugs, the invention relates to pharmaceutical new use of loganin, especially the use of loganin in preparation of drugs or health care products for improving sleep. The loganin provided by the invention is one of the main chemical components of Cornaceae plant cornus officinalis, the chemical formula is C17H26O10, and the molecular weight is 390.38. Animal experiments confirm that loganin can significantly prolong the total sleep time of mice, and has the characteristic of dose dependent increase of sleep amount. Preliminary action mechanism study shows that loganin possibly induces sleep by increasing the level of 5-HT in mouse brain. To sum up, loganin can be prepared into drugs and health care products with sedative and hypnotic effects, the made dosage forms include granules, tablets, capsules, granules, electuaries, oral liquid, dripping pills, pellets or injections.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new medicine application of loganin, in particular to the application of loganin in preparing medicine for improving sleep. technical background [0002] One-third of life is spent in sleep. Only with good sleep can we maintain normal life, work and study. It can be said that sleep is the premise and basis for maintaining all human activities. However, in recent years, with the increasingly fierce social competition and the continuous acceleration of people's life rhythm, sleep disorders have gradually become a problem for people, and the most prominent one is insomnia. According to the research report of the World Health Organization, about 66% of people in the world have sleep disorders at present, and the insomnia rate is also as high as 10% to 20% in my country. Insomnia not only easily leads to organic diseases, but also weakens people's immunity and consumes a lot of people's body....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P25/20
CPCA61K31/352
Inventor 续洁琨张维库乔灏祎赫军叶贤胜
Owner BEIJING UNIV OF CHINESE MEDICINE
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