A kind of dimetridazole soluble powder and preparation method thereof
A dimenidazole and soluble technology, applied in the field of veterinary chemical pharmaceutical preparations, can solve the problems of low solubility of β-cyclodextrin, insoluble dimenidazole in water, unable to be administered in drinking water, etc. Dissolution rate and saturation solubility, improve bioavailability and efficacy, and meet the effect of clinical dosage
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Embodiment 1
[0028] A Dimenidazole soluble powder consisting of 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose,
[0029] Its preparation method comprises the following steps:
[0030] (1) Micronization and pulverization: Add 20 parts of Dimenidazole into a side-wall vibrating pulverizer, pulverize and grind for 60 minutes, and discharge;
[0031] (2) Mixing: mix the above-mentioned 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose to obtain a semi-finished product of Dimenidazole soluble powder with a content of 20%. ;
[0032] (3) Packing: The above-mentioned semi-finished products are weighed and passed the inspection, and put into aluminum foil bags for sealed storage.
Embodiment 2
[0034] A Dimenidazole soluble powder consisting of 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose,
[0035] Its preparation method is characterized in that: it comprises the following steps:
[0036] (1) Micronized pulverization: Add 20 parts of Dimenidazole into the jet pulverizer for pulverization and discharge;
[0037] (2) Mixing: mix the above-mentioned 20 parts of Dimenidazole, 10 parts of PVP K30, 3 parts of Poloxamer 188 and 67 parts of anhydrous glucose to obtain a semi-finished product of Dimenidazole soluble powder with a content of 20%. ;
[0038] (3) Packing: The above-mentioned semi-finished products are weighed and passed the inspection, and put into aluminum foil bags for sealed storage.
Embodiment 3
[0040] A Dimenidazole soluble powder consisting of 20 parts of Dimenidazole, 10 parts of PVP K30, 2 parts of Poloxamer 188, 2 parts of sodium lauryl sulfate and 71 parts of anhydrous lactose,
[0041] Its preparation method comprises the following steps:
[0042] (1) Micronization and pulverization: Add 20 parts of Dimenidazole and 10 parts of PVP K30 into a side-wall vibrating pulverizer for pulverization and grinding for 90 minutes, and discharge;
[0043] (2) Mixing: Mix 20 parts of Dimenidazole, 10 parts of PVP K30, 2 parts of Poloxamer 188, 2 parts of sodium lauryl sulfate and 71 parts of anhydrous lactose to obtain a content of 20% Semi-finished products of Dimetridazole soluble powder;
[0044] (3) Packing: The above-mentioned semi-finished products are weighed and passed the inspection, and put into aluminum foil bags for sealed storage.
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