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Medicament matrix composition, preparation method and usage thereof

A technology of a matrix composition and a medicine is applied to the gel patch matrix composition and the field of preparing the gel patch, and can solve problems such as loss of viscosity, insufficient reflection of the quality of the gel patch, and leakage of the plaster.

Inactive Publication Date: 2016-09-07
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these indicators are not enough to reflect the quality of the gel plaster. The gel plaster that meets the requirements of the Pharmacopoeia still has quality problems such as peeling off, loss of viscosity, and ointment leakage.
Moreover, for the adhesion that is crucial in the quality index of gel plaster, although the Pharmacopoeia stipulates the determination methods and experimental devices for initial adhesion, holding force, peel strength and adhesion, these four indicators are independent. indicators, without taking their balance into account
[0005] Therefore, at present, the market still lacks a matrix with balanced initial adhesion, holding strength, peel strength and adhesion, so that it can be mixed with various drugs to treat related diseases

Method used

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  • Medicament matrix composition, preparation method and usage thereof
  • Medicament matrix composition, preparation method and usage thereof
  • Medicament matrix composition, preparation method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Take the raw material composition of following weight:

[0049] PVPK903.87g

[0050] PAAS700 6.97g

[0051] Tartaric acid 0.25g

[0052] Aluminum glycylate 0.30g

[0053] Glycerin 35.00g

[0054] Purified water 43.61g

[0055] (2) Dissolve PVPK90 and tartaric acid in purified water, fully swell, as phase A.

[0056] (3) Mix PAAS700 and aluminum glycolate evenly, disperse them in glycerin, stir evenly at a stirring speed of 60r / min, and stir for about 15min to obtain phase B.

[0057] (4) Add phase A to phase B at one time, first stir at 60r / min, then increase the stirring speed to about 120r / min, and stir for about 15min to form a uniform paste.

[0058] (5) At 60°C, through vacuum-atmospheric pressure-vacuum three times of alternating pressure changes to remove the air bubbles in the paste, that is, the present invention has a balanced initial adhesion, adhesion, peel strength and adhesion Powerful gel patch base.

Embodiment 2

[0060] (1) Take the raw material composition of following weight:

[0061] PVPK903.80g

[0062] PAAS700 6.90g

[0063] Tartaric acid 0.24g

[0064] Aluminum glycylate 0.28g

[0065] Glycerin 34.00g

[0066] Purified water 42.35g;

[0067] (2) Dissolve PVPK90 and tartaric acid in purified water, fully swell, as phase A.

[0068] (3) Mix PAAS700 and aluminum glycolate evenly, disperse them in glycerin, stir evenly at a stirring speed of 60r / min, and stir for about 20min to obtain phase B.

[0069] (4) Add phase A to phase B at one time, first stir at 60r / min, then increase the stirring speed to about 120r / min, and stir for about 20min to form a uniform paste.

[0070] (5) At 60°C, through vacuum-atmospheric pressure-vacuum 4 times of alternating pressure changes to remove the air bubbles in the paste, that is, the present invention has a balanced initial adhesion, adhesion, peel strength and adhesion Powerful gel patch base.

Embodiment 3

[0072] (1) Take the raw material composition of following weight:

[0073] PVPK903.90g

[0074] PAAS700 7.00g

[0075] Tartaric acid 0.26g

[0076] Aluminum glycylate 0.32g

[0077] Glycerin 36.00g

[0078] Water 45.50g

[0079] (2) Dissolve PVPK90 and tartaric acid in water, fully swell, as phase A.

[0080] (3) Mix PAAS700 and aluminum glycolate evenly, disperse them in glycerin, stir evenly at a stirring speed of 60r / min, and stir for about 15min to obtain phase B.

[0081] (4) Add phase A to phase B at one time, first stir at 60r / min, then increase the stirring speed to about 120r / min, and stir for about 18min to form a uniform paste.

[0082] (5) At 60°C, through vacuum-atmospheric pressure-vacuum three times of alternating pressure changes to remove the air bubbles in the paste, that is to say, the present invention has a balanced initial adhesion, holding force, peel strength and Adhesive gel patch base.

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PUM

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Abstract

The invention relates to a medicament matrix composition and a preparation method. PVPK90 (polyvinylpyrrolidone K90), PAAS700 (sodium polyacrylate 700), dihydroxyaluminium aminoacetate, tartaric acid, glycerol and purified water are taken as raw materials and are mixed, stirred and formed into the medicament matrix composition. The matrix has the characteristics of primary viscous force, keeping viscous force, peel strength, adhesive force balancing, and the like; the matrix is mixed with the raw material drugs; the materials are uniformly stirred and mixed, coated, dried, checked and packaged, thereby acquiring the gel plaster used for treating the related diseases.

Description

1. Technical field [0001] The present invention relates to a kind of medicine matrix composition and its preparation method and application, in particular to a kind of gel plaster matrix composition, its preparation method and its application for preparing gel plaster. 2. Background technology [0002] Gel plaster refers to the plaster made by mixing the raw drug with a suitable hydrophilic matrix and coating it on the backing material. Commonly used bases include sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerin and micronized silica gel etc. my country carried out the research on the gel plaster (formerly known as the Babu ointment) in the 1980s, and by the early 1990s, the traditional Chinese medicine Babu ointment began to be produced on a large scale. So far, the domestic marketed gel plaster drugs include Shanghai Leiyunshang Pharmaceutical Co., Ltd.'s joint pain relieving babu ointment, compound Bauhinia Xiaoshang babu ointment and Chanwu gel oin...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/12A61K47/10A61K47/18
CPCA61K9/7061A61K9/7053
Inventor 马秉智张相林吴东盼陆进鞠海阎小萍
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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