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Surgical anti-adhesion gel and preparation method thereof

An anti-adhesion and gel technology, applied in the field of biological materials, can solve problems such as hidden safety hazards and the inability of anti-adhesion products to degrade quickly, and achieve the effect of better effect, excellent bacteriostatic and anti-mildew properties.

Active Publication Date: 2019-02-26
上海建华精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The limitation of current anti-adhesion products is that they cannot be degraded quickly, resulting in some safety hazards caused by residues in the body after surgery

Method used

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  • Surgical anti-adhesion gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Gel formula

[0025] An anti-adhesion gel for surgery, which comprises the following components in parts by weight: 4 parts of hydroxybutylated chitosan, 5 parts of polylactic acid, 1 part of sodium chloride, 1 part of auxiliary material, 0.08 part of borneol, 1000 parts of water for injection and Borate buffer, the amount of borate buffer added is to make the pH of the gel 6.0.

[0026] Wherein, the auxiliary material is prepared from hypromellose, mannitol, carbomer, sodium bisulfite, and glycerin according to the weight ratio of 1:3.5:3:1:2.

[0027] 2. Gel preparation method

[0028] (1) Take 40% volume of sterile water for injection, cool it to 55°C, and add it to the reaction vessel;

[0029] (2) Weighing the polylactic acid and hydroxybutylated chitosan in the formula amount into a reaction vessel, stirring evenly until completely dissolved, to obtain a raw material solution;

[0030] (3) Take the remaining amount of water for injection into another reactio...

Embodiment 2

[0035] 1. Gel formula

[0036] An anti-adhesion gel for surgery, which comprises the following components in parts by weight: 3 parts of hydroxybutylated chitosan, 6 parts of polylactic acid, 1.5 parts of sodium chloride, 0.5 parts of auxiliary materials, 0.05 parts of borneol, 1000 parts of water for injection and Borate buffer solution, the addition amount of borate buffer solution is to make the pH of the gel be 7.0.

[0037] Wherein, the auxiliary material is prepared from hypromellose, mannitol, carbomer, sodium bisulfite, and glycerin according to the weight ratio of 1:3:3:2:2.

[0038] 2. Gel preparation method

[0039] (1) Take 50% volume of sterile water for injection, cool it to 50°C, and add it to the reaction vessel;

[0040] (2) Weighing the polylactic acid and hydroxybutylated chitosan in the formula amount into a reaction vessel, stirring evenly until completely dissolved, to obtain a raw material solution;

[0041] (3) Take the remaining amount of water for ...

Embodiment 3

[0046] 1. Gel formula

[0047] An anti-adhesion gel for surgery, which comprises the following components in parts by weight: 6 parts of hydroxybutylated chitosan, 3 parts of polylactic acid, 2 parts of sodium chloride, 0.8 parts of auxiliary materials, 0.1 part of borneol, 1000 parts of water for injection and Borate buffer solution, the addition amount of borate buffer solution is to make the pH of the gel be 9.0.

[0048] Wherein, the auxiliary material is prepared from hypromellose, mannitol, carbomer, sodium bisulfite, and glycerin according to the weight ratio of 1:4:4:1:2.

[0049] 2. Gel preparation method

[0050] (1) Take 60% volume of sterile water for injection, cool it to 60°C, and add it to the reaction vessel;

[0051] (2) Weighing the polylactic acid and hydroxybutylated chitosan in the formula amount into a reaction vessel, stirring evenly until completely dissolved, to obtain a raw material solution;

[0052] (3) Take the remaining amount of water for inje...

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Abstract

The invention belongs to the field of biological materials and particularly relates to an operation anti-adhesion gel and a preparation method thereof. The operation anti-adhesion gel is prepaerd from the following ingredients in parts by weight: 3-6 parts of hydroxyl butyl chitosan, 3-6 parts of polylactic acid, 1-2 parts of an isoosmotic adjusting agent, 0.5-1 part of an accessory, 0.05-0.1 part of borneol, 1000 parts of water for injection and a pH regulator, wherein the addition amount of the pH regulator ensures that the pH of the gel is 6.0-9.0. The prepared operation anti-adhesion preparation is capable of not only preventing adhesion between tissues or organs, but also has a bacteriostatic effect and can be rapidly degraded.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a surgical anti-adhesion gel and a preparation method thereof. Background technique [0002] After surgery, tissue adhesion is prone to occur, which is not only a common clinical phenomenon in the field of surgery, but also a process that patients must go through during the healing process. Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs. If the adhesion phenomenon occurs in the abdominal cavity, pelvic bone and other operations, it will cause serious complications, such as abdominal and pelvic cavity can cause adhesive ileus, recurrent laryngeal nerve injury after thyroid surgery and pelvic tissue adhesion. female infertility. [0003] Adhesions occur for several main reasons: inflammation due to ischemia, trauma during surgery, presence of foreign bodies in the body, bacterial infection at bleeding si...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61L31/04A61L31/14A61L31/16
CPCA61L31/041A61L31/148A61L31/16A61L2300/404C08L5/08C08L67/04
Inventor 陈晚华吴剑英张军东常臻
Owner 上海建华精细生物制品有限公司