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Application of Netrin-4 in preparing preparation for detecting stomach cancer and prognosis marker

A technology of prognostic markers and uses, applied in the field of cell biology, can solve problems such as unclear molecular mechanisms, no literature reports, and lack of

Active Publication Date: 2016-10-05
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Similar to Ntn4, Neo is highly expressed in highly invasive tumors, and Neo has been shown to promote the proliferation and migration of gastric cancer cells; although many studies have shown that Ntn4 is involved in tumorigenesis and development, so far its role in gastric cancer The role has not been reported in the literature, and whether Ntn4 can be used as a serum or plasma marker for the diagnosis and prognosis of gastric cancer still lacks corresponding research support; in addition, whether Neo plays a role in the effect of Ntn4 on gastric cancer and the corresponding molecular mechanism is still unclear

Method used

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  • Application of Netrin-4 in preparing preparation for detecting stomach cancer and prognosis marker
  • Application of Netrin-4 in preparing preparation for detecting stomach cancer and prognosis marker
  • Application of Netrin-4 in preparing preparation for detecting stomach cancer and prognosis marker

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Embodiment 1

[0035]Randomly select paraffin wax specimens of gastric cancer tissues from 82 patients who underwent radical gastrectomy in the Department of General Surgery of Huashan Hospital in Shanghai from January 2005 to December 2005 and have complete medical history data. Margin, 2cm from the edge of the tumor). All tissue samples were confirmed as gastric adenocarcinoma by conventional pathological sections HE staining. The pathological diagnosis was jointly determined by two pathologists, and the TNM staging was carried out according to the 2010 American Joint Cancer Society (AJCC) gastric cancer TNM staging standard (seventh edition). The patients were followed up until July 2011. During the follow-up period, a total of 34 patients were lost to follow-up, and the follow-up rate was 58.5%. The preoperative serum samples of 52 patients newly diagnosed with gastric cancer between June 2014 and November 2014 were randomly selected. At the same time, the sera of 52 healthy patients we...

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Abstract

The invention belongs to the technical field of cell biology, and relates to application of Netrin-4 in preparing a preparation for detecting stomach cancer and a prognosis marker. Experiments display that Ntn4 is combined with a ligand neogenin thereof to activate cancer promoting paths such as Jak / Stat, PI3K / Akt and ERK / MAPK, thereby achieving the effects of promoting gastric cancer cell proliferation and invasion. Experiment results show that Ntn4 has remarkable high expression in both a serum sample and a tumor tissue sample of a patient with gastric cancer, high expression is in negative correlation with the lifetime of the patient and in positive correlation with TNM staging, it shows that Ntn4 can be used as potential serological indicator for gastric cancer and prognosis and used for preparing the preparation for detecting stomach cancer and the prognosis marker. The preparation comprises a reagent and a kit which are used for detecting stomach cancer and the prognosis marker.

Description

technical field [0001] The invention belongs to the technical field of cell biology, and relates to the use of Netrin-4 in preparing preparations for detecting gastric cancer and prognostic markers; wherein, the Netrin-4 is a secreted protein homologous to laminin. Background technique [0002] According to reports, gastric cancer is one of the common malignant tumors, and its mortality rate is second only to lung cancer in the world, ranking second in the mortality rate of cancer. At present, due to the limitations of clinical diagnosis and treatment, especially the lack of serological diagnostic indicators, most gastric cancer patients have already reached the advanced stage when they are diagnosed, and basically lose the opportunity for radical surgery. Studies have shown that serum pepsinogen and gastrin-17 may be used for early screening of gastric cancer, but their specificity and sensitivity still need to be verified by large sample data. [0003] The prior art discl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
Inventor 刘杰杨冬琴吕彬张骏章琦
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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