Carbon nanosphere preparation as well as preparation method and anti-helicobacter pylori infection experiment method thereof

A technology against Helicobacter pylori and Helicobacter pylori, which is applied in antibacterial drugs, material inspection products, carbon active ingredients, etc., can solve the problems of high infection recurrence rate, aggravated drug adverse reactions, and increased drug dosage. Achieving powerful anti-Helicobacter pylori effect, ensuring high stability, and low dose effect

Inactive Publication Date: 2016-10-12
成都本珍纳米生物科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] In order to solve the problem that the traditional therapy for the treatment of Helicobacter pylori infection in the prior art has more and more serious antibiotic resistance, resulting in increased dosage of drugs, prolonged course of treatment, aggravated adverse drug reactions and high infection recurrence rate, this paper A carbon nanosphere preparation provided by the invention is composed of a mixture of carbon nanospheres and a dispersion liquid, the concentration of the carbon nanosphere preparation is 0.1% to 1.0%, wherein the dispersion liquid is deionized water, and more than 95% of the carbon The particle size of nanospheres is 5-30nm

Method used

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  • Carbon nanosphere preparation as well as preparation method and anti-helicobacter pylori infection experiment method thereof
  • Carbon nanosphere preparation as well as preparation method and anti-helicobacter pylori infection experiment method thereof
  • Carbon nanosphere preparation as well as preparation method and anti-helicobacter pylori infection experiment method thereof

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preparation example Construction

[0047] As a specific embodiment, the preparation method of carbon nanosphere preparation comprises the following steps:

[0048] 1. Using graphene as the raw material to process and prepare carbon nanospheres;

[0049] 2. Use transmission electron microscopy to screen carbon nanospheres whose particle size meets the requirements, wherein carbon nanospheres with a particle size of 5-30 nm account for more than 95%; carbon nanospheres are dispersed in a single spherical shape;

[0050] 3. According to the concentration requirements, weigh the carbon nanospheres screened in step 2 and deionized water respectively, and set aside;

[0051] 4. Mix and disperse the carbon nanospheres obtained in step 3 and deionized water;

[0052] 5. Stir the mixed liquid obtained by mixing in step 4, wherein the stirring time is 10-20 minutes, and the stirring speed is 60-80 r / min;

[0053] 6. Ultrasonic treatment is performed on the mixed solution after the stirring treatment in step five, where...

Embodiment 1

[0058] Example 1: Preparation of carbon nanospheres and deionized water.

[0059] Graphene is used as a raw material to process and prepare carbon nanospheres, and the carbon nanospheres with a particle size of 5-30 nm are screened under a transmission electron microscope for future use. It should be ensured that carbon nanospheres with a particle size of 5-30 nm account for more than 95% of the total amount.

[0060] Prepare deionized water and set aside.

Embodiment 2

[0061] Example 2: Preparation of 1.0% carbon nanosphere preparation.

[0062] According to the concentration requirement of 1.0%, a certain amount of carbon nanospheres and deionized water were mixed and dispersed, and stirred for 20 minutes, wherein the stirring speed was 80 r / min.

[0063] Ultrasonic treatment was performed on the stirred mixed solution, wherein the whole ultrasonic time was set to 20 minutes, the single ultrasonic time was set to 3 seconds, the interval time was set to 3 seconds, and the ultrasonic intensity was set to 100w (ultrasound in a low-temperature water bath).

[0064] The pH value of the mixed solution after ultrasonication is adjusted with sodium bicarbonate-sodium carbonate buffer solution, and the final pH value of the mixed solution is adjusted to 7.6, so as to obtain a carbon nanosphere preparation that meets the requirements.

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Abstract

The invention discloses a carbon nanosphere preparation as well as a preparation method and an anti-helicobacter pylori infection experiment method thereof. The carbon nanosphere preparation is prepared by mixing carbon nanospheres and dispersion liquid; the concentration of the carbon nanosphere preparation is 0.1 percent to 1.0 percent; the dispersion liquid is de-ionized water and the grain diameter of not less than 95 percent of the carbon nanospheres is 5nm to 30nm. The carbon nanosphere preparation has the advantages of low cost, easiness for manufacturing, good stability, high safety and good anti-helicobacter pylori infection effect. The preparation method of the carbon nanosphere preparation has the characteristics of easiness of implementation, simple process and convenience for operation. The anti-helicobacter pylori infection experiment method of the carbon nanosphere preparation has the characteristics of convenience for implementation, scientificity and rationality. The carbon nanosphere preparation disclosed by the invention can be developed as a new drug for treating helicobacter pylori infection, so that a new idea is provided for developing anti-helicobacter pylori infection medicines and a new strategy is provided for prevention and treatment of anti-helicobacter pylori infection.

Description

technical field [0001] The invention relates to a carbon nanometer material, in particular to a carbon nanosphere preparation and a preparation method thereof, and an experimental method for the carbon nanosphere preparation to resist Helicobacter pylori infection. Background technique [0002] Helicobacter pylori (Hp) infection-related diseases, such as gastritis, gastric ulcer, duodenal ulcer and gastric cancer, seriously endanger human health. According to the statistics of the World Health Organization (WHO), about 50% of the world's population is infected with Helicobacter pylori, especially in my country, where the condition of Helicobacter pylori is relatively severe, and about 60% of people are infected with Helicobacter pylori. WHO has classified Helicobacter pylori A class of carcinogens for gastric cancer. Currently, H. pylori infection is treated with a combination of antibiotics and gastric acid suppressants. However, due to the increasingly serious resistance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44G01N33/50A61K9/14A61P31/04
CPCA61K9/14A61K33/44G01N33/5008
Inventor 田汉文
Owner 成都本珍纳米生物科技有限公司
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