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New application of honeysuckle liquid

A technology of honeysuckle water and usage, applied in the field of traditional Chinese medicine

Active Publication Date: 2020-11-03
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the abuse and misuse of ephedrine and other stimulants are common, and adverse reactions caused by improper use of ephedrine occur frequently
Methadone, clonidine and other drugs are commonly used at home and abroad to eliminate stimulant addiction or withdrawal symptoms, but these drugs themselves have certain problems of addiction and drug resistance, so the selection of drugs with less toxic side effects, less dependence and Traditional Chinese medicine with low drug resistance is of great significance for reducing or reducing the damage caused by excitatory drugs to the tissues and organs of the body
At present, there is no special curative effect of anti-ephedrine cardiomyocyte injury Chinese medicine

Method used

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  • New application of honeysuckle liquid
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  • New application of honeysuckle liquid

Examples

Experimental program
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Embodiment Construction

[0011] The present invention is further illustrated in conjunction with examples.

[0012] Liquid preparation

[0013] According to the preparation method of traditional Chinese medicine decoction, take 100g of honeysuckle, soak in water for 1 hour, boil for 30 minutes, filter the medicine juice, add the dregs and decoct with water for 30 minutes to filter the medicine juice, combine the two medicine solutions, and then use a rotary evaporator to decoct the medicine juice. The decoction is concentrated to make 0.9~1.5g / mL crude drug honeysuckle liquid.

[0014] Protective Effect of Honeysuckle Liquid on Cardiomyocyte Injury Induced by Ephedrine

[0015] Ninety Kunming mice born 10 days old were selected and randomly divided into blank control group, experimental control (ephedrine) group and experimental (ephedrine + honeysuckle) group. The experimental control group and the experimental group were continuously (1~5d, 6~10d, 11~15d) intraperitoneally injected with increasing...

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Abstract

The invention discloses honeysuckle flower liquid resistant to ephedrine cardiomyocyte injury. The honeysuckle flower liquid is raw liquid medicine decoction of 0.9-1.5 g / mL. Based on extensive studies of honeysuckle flower, it is found that the honeysuckle flower liquid can promote cell metabolism, improve the antioxidant capacity of histocyte, inhibit peroxidatic reaction of cell membrane lipids, maintain membrane integrity and permeability, reduce structural damage of tissue and reduce the activity of serum CK and CK-MB, also has antioxidant, anti-inflammatory and cardiac histiocyte protecting effects, and can effectively reduce or relieve the damage of ephedrine to myocardial cells. Novel application of the honeysuckle flower liquid is realized, and the novel application has certain reference meaning for development and utilization of the honeysuckle flower medicinal resource in future.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a new application of honeysuckle liquid for resisting ephedrine cardiomyocyte damage. Background technique [0002] Ephedrine is the main ingredient in drugs for the treatment of colds, allergic reactions, bronchial asthma, and nasal mucosal congestion. At the same time, ephedrine is also a sympathomimetic drug. As an important raw material for the synthesis of methamphetamine and ecstasy, long-term use or improper use can easily cause Toxic and side effects of the central nervous system, serious drug dependence, pathological damage to the tissue structure of the body, and death in severe cases. Therefore, it is of great significance for the development of medicine to study the protective effect of Chinese herbal medicine on animals or human body, and to develop Chinese medicine preparations that have no toxic side effects on the body and are resistant to dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/355A61P9/00
CPCA61K36/355
Inventor 俞诗源刘婷婷李重阳彭静
Owner NORTHWEST NORMAL UNIVERSITY