Pharmaceutical composition for the treatment of femoral shaft fracture and preparation method thereof

A composition and technology of femoral backbone, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of delayed healing, non-union of fractures, limited types of drugs, etc., to promote the generation of bone cells, and the production process is simple and difficult. The effect of drug resistance

Inactive Publication Date: 2016-10-12
YANTAI MINWANG ELECTROMECHANICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

6. Premature weight bearing: unreasonable early movement, tearing the newly formed fibrous callus or bony callus, resulting in fracture nonunion or delayed union
7. Insufficient blood supply to the stump: tissue regeneration requires sufficient blood supply
The types of drugs for the treatment of femoral shaft fractures are limited and cannot meet the needs of clinical adjuvant therapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0073] When the dosage form of the pharmaceutical composition is a patch, its preparation method comprises the following steps:

[0074] Step 1: Mix gingivitis medicine, white pearl tree, Shi Pengzi, Tie hoopsan, Qianda hammer, pillar Polygonum, chestnut marmoset and scorpion according to the stated ratio, and use 3 to 5 times the mass of the obtained mixture Soak in ethanol with an alcohol concentration of 85% to 95%, extract after heating and reflux for 2 to 4 hours, and filter to obtain the first filtrate; use the filter residue again with an alcohol concentration of 85% to 1 to 2 times the mass of the obtained mixture Soak in 95% ethanol, heat and reflux for 1 to 2 hours, extract, filter to obtain the second filtrate; combine the first and second filtrates, recover ethanol under reduced pressure and concentrate until the concentration of the medicinal solution is 0.7 to 0.9 g of crude drug / mL, eluted by a macroporous adsorption resin column with a volume of 5L, first elut...

Embodiment 1

[0086] Example 1 Patches

[0087] The production process of the patch preparation of the present invention is as follows: take 140g of white residual flowers, 150g of Pueraria japonica juice, 350g of jujube, 250g of Huxincao, 220g of Dipixiao, 150g of Jiangzhenxiang, 320g of Viola, 200g of Panax notoginseng, and 170g of Daqingye , licorice 400g, elderberry 250g, salvia miltiorrhiza 220g, dental malnutrition medicine 140g, white bead tree 330g, stone pendant 200g, iron hoop powder 210g, thousand hammer 300g, pillar polygonum 220g, shepherd's weed 320g, sage 120g, Cimicifuga 200g , Yisaoguang 320g, wolfberry fruit 150g and Tongjingcao 200g;

[0088] Step 1: Mix gingivitis medicine, white pearl tree, Shi Pengzi, Tie hoopsan, Qianda hammer, Polygonum pilosula, marmoset and scorpion according to the stated ratio, and use 4 times the mass of the obtained mixture with alcohol Soak in ethanol with a concentration of 90%, extract after heating and reflux for 3 hours, and filter to obt...

Embodiment 2

[0092] Example 2 Granules

[0093] The preparation process of the granules of the present invention is as follows: get 180g of white residual flower, 200g of Pueraria japonica juice, 400g of jujube, 300g of Huxincao 300g, 240g of Dipixiao, 210g of Jiangzhenxiang, 320g of creeping Viola 320g, 240g of Panax notoginseng, 150g of Daqingye, 300g of licorice, 250g of elderberry, 190g of salvia miltiorrhiza, 160g of dental malnutrition, 320g of white pearl tree, 200g of Shi Pengzi, 220g of iron hoop powder, 300g of thousand hammers, 260g of pillar polygonum, 310g of shepherd's weed, 130g of 菥蓂, 250g of Cimicifuga, Yisaoguang 330g, medlar 150g and Tongjingcao 300g;

[0094] The first step is to mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration 6 times that of the mixture and be 95% ethanol, heat to boiling and reflux for 4 hours, filter, and slow down the mixture at a rate of 2 ml per minute by percolation method. Slow percolatio...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for the treatment of femoral shaft fracture and a preparation method thereof. The pharmaceutical composition is made from the following raw materials: Rosa multiflora, juice of oriental grape, jujube, Cyperus Michelianus, delavay pararuellia herb, Tanarius major, violet Herba, pseudo-ginseng, herba taching, licorice, elderberry, the root of red-rooted salvia, scabrid smallhooked hedyotis herb, Gaultheria pyroloides, Ceylon houndstongue leaf or root-bark, chun spicebush root, rhizoma polygoni suffulti, Adenophora trachelioides, Thlaspi arvense, cimicifugae foetidae, one strike decoction, medlar and sivery aleuritopteris herb. The invention has the beneficial effects that the pharmaceutical composition has the effects of invigorating qi, generating muscle, and promoting blood circulation to remove meridian obstruction, can remove blood stasis, generate new muscle, repair bone, promote the formation of bone cells and recovery of peripheral nerve and muscle; and the efficacy directly reaches the lesions. The invention has the advantages of simple production process, little side or toxic effects, low cost, no resistance and no recurrence.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating femoral shaft fractures and a preparation method. Background technique [0002] The femur is the longest tubular bone in the human body. The femoral shaft includes the backbone from 2 to 5 cm below the trochanter to 2 to 5 cm above the femoral condyle. The femoral shaft is surrounded by three groups of muscles. Due to the well-developed muscles of the thigh, there are often dislocations and overlaps after fractures. The distal end of the fracture often has a tendency to move inward, and the fracture that has been aligned often has a tendency to bulge outward. This kind of displacement and angulation tendency should be corrected and prevented during fracture treatment. When the lower 1 / 3 of the femur is fractured, because the blood vessels are located behind the femoral fracture, and the distal end of the fracture is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P19/08A61P29/00
CPCA61K36/8905A61K9/0014A61K9/06A61K9/1652A61K9/7023A61K36/11A61K36/19A61K36/195A61K36/258A61K36/28A61K36/30A61K36/31A61K36/315A61K36/342A61K36/35A61K36/45A61K36/484A61K36/537A61K36/54A61K36/60A61K36/704A61K36/71A61K36/725A61K36/738A61K36/74A61K36/75A61K36/815A61K36/855A61K36/86A61K36/87A61K47/10A61K47/46A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 姜文升
Owner YANTAI MINWANG ELECTROMECHANICAL TECH CO LTD
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