A kind of mesoporous silica loaded bioglass composite material

A technology of mesoporous silica and composite materials, applied in the field of materials, can solve the problems of rising product cost, unstable bio-glass materials, limiting the practical application of bio-glass, etc., and achieve the effect of simple preparation and stable storage.

Active Publication Date: 2019-01-08
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrolysis of bioglass materials is the main source of its biological activity, which also leads to the unstable existence of bioglass materials in aqueous solution environments.
Therefore, the current toothpaste with bioglass as the active ingredient is an anhydrous system (generally glycerin system), which not only leads to a substantial increase in product costs, but also limits the practical application of bioglass in many aqueous systems such as oral restorations.

Method used

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  • A kind of mesoporous silica loaded bioglass composite material
  • A kind of mesoporous silica loaded bioglass composite material
  • A kind of mesoporous silica loaded bioglass composite material

Examples

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Embodiment Construction

[0022] The present invention will be described in detail below in conjunction with specific embodiments.

[0023] Preparation Example

[0024] The mesoporous silica-loaded bioglass composite material of the present invention is prepared by the following method:

[0025] 1. Synthesis of mesoporous silica material: First, dissolve 0.50 g Poloxamer F127 and 1.25 g KCl in 30.0 ml HCl solution with a concentration of 2 M, and stir until completely dissolved. After the solution becomes clear, dissolve 0.60 g TMB (mesitylene) was added to the clear solution, and the stirring was continued for 1 h, then 2.23 g tetraethyl orthosilicate (TEOS) was added dropwise to the solution, and the solution was vigorously stirred at 15ºC (600-1000 rpm) 24 h. Then it was transferred to the reactor, hydrothermally reacted at 220 ºC for 24 h, filtered and washed, dried naturally in the air, and finally placed in a muffle furnace for calcination at 550 ºC for 6 h, cooled to room temperature The obta...

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Abstract

The invention discloses a mesoporous silica supported bioglass composite. The composite takes a mesoporous silica material as a carrier; bioglass materials are supported in holes of the mesoporous silica material. The composite prepared from mesoporous silica supported bioglass can stably exist in an aqueous phase environment, controllable release can be performed by means of ultrasound, and the activity of the bioglass is not changed.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a composite material of mesoporous silica loaded with biological glass. Background technique [0002] Bioactive glass material (bio-active glass), also known as bioglass (bioglass), refers to mainly SiO 2 -Na 2 O-CaO-P 2 o 5 based reactive glass materials. Since it was successfully developed by Professor Hench and others in 1971, its application research in the restoration of biological hard tissues (bones, teeth, etc.) and drug carriers has become a research hotspot in biochemistry, materials science, and medicine. In the early days of the invention of bioglass, it was mainly used in the oral cavity, such as the clinical treatment of oral diseases such as periodontal disease treatment, root canal filling, and prevention of alveolar atrophy. Today, dental medical bioglass has been commercialized and produced, and has gradually expanded from clinical treatment to oral car...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/25A61Q11/00C04B41/85
CPCA61K8/25A61Q11/00C04B41/009C04B41/5022C04B41/85C04B35/14C04B41/4537C04B41/0072
Inventor 万昆明刘建兰李莉
Owner NANJING TECH UNIV
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