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LC Columns with Structured Walls

A liquid chromatography, structural part technology, applied in the field of LC columns and their manufacture, which can solve the problems of reducing resolution, increasing the speed of analyte dispersion, etc.

Inactive Publication Date: 2019-04-12
AGILENT TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This flow non-uniformity increases the velocity of analyte dispersion and thus reduces the resolution of the measured peaks eluted from the column

Method used

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  • LC Columns with Structured Walls
  • LC Columns with Structured Walls
  • LC Columns with Structured Walls

Examples

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Embodiment Construction

[0023] figure 1 is a cross-sectional view of an example of a conventionally configured liquid chromatography (LC) column 100 . The post 100 generally extends along a central (or longitudinal) axis 102 from a first post end 104 to a second post end 106 . The features of the column 100 at the first column end 104 and the second column end 106 may be identical, in which case the designation of column end 104 or column end 106 functioning as an inlet or outlet port is arbitrary. of. Column 100 generally includes a column wall 110 that is elongated along axis 102 and surrounds a column interior 112 . Wall 110 is generally cylindrical (eg, a tube), and thus column interior 112 is generally a cylindrical bore between column ends 104 and 106 . Wall 100 includes components at column ends 104 and 106 for providing a fluidic interface between column interior 112 and tubing or other fluidic components external to column 100 . For example, column 100 may include a first end fitting 114...

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Abstract

A liquid chromatography (LC) column comprising a wall having a length along a central axis from an inlet end to an outlet end, the wall surrounding a column interior and having a column radius relative to the central axis, the wall Including a structural portion configured such that the pillar radius varies along the length; and a plurality of particles packed inside the pillar, wherein at least some of the particles are in contact with the structural portion.

Description

[0001] This application claims the benefit of US Provisional Patent Application No. 61 / 879,485, entitled "Liquid Chromatography Columns With Structural Walls," filed September 18, 2013, the contents of which are hereby incorporated by reference in their entirety. technical field [0002] The present invention relates generally to liquid chromatography (LC), and more particularly to LC columns and methods for their manufacture. Background technique [0003] Liquid chromatography (LC) is a technique used to analytically or preparatively separate a liquid sample material of interest (eg, a mixture of different chemical compositions) into its constituent components. During the chromatographic separation process, sample material is transported in a mobile phase (usually one or more solvents). Force the sample / mobile phase through a stationary phase that is incompatible with the mobile phase. Typically, the stationary phase is provided in the form of a mass of particles (packed o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/26
CPCG01N30/6065G01N30/6086G01N30/606
Inventor 洪峰·尹里德·A·布伦南艾瑞克·利斯特罗杰·斯洛克姆
Owner AGILENT TECH INC
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