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Vascular protection pharmaceutical composition and application thereof

A technology of vascular protection agent and composition, which is applied in the field of vascular protection pharmaceutical composition, and can solve problems such as small amount

Active Publication Date: 2016-11-09
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with a large number of natural medicinal materials, there are still a small number of relevant reports on natural medicinal extracts as vascular protective agents.

Method used

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  • Vascular protection pharmaceutical composition and application thereof
  • Vascular protection pharmaceutical composition and application thereof
  • Vascular protection pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051]

[0052] The following describes the isolation and culture process of human umbilical vein endothelial cells HUVEC as test cells.

[0053] 1. Experimental Preparation

[0054] 25cm 2 Cell culture flasks were coated with 2% gelatin, stored overnight in a refrigerator at 4°C, and placed in a cell culture incubator at 37°C for more than 30 minutes before use. After the gelatin was discarded, the flasks were rinsed three times with PBS.

[0055] After the 500mL blue-necked glass bottle is sterilized in an autoclave, add 300mL pre-cooled PBS to transport the umbilical cord.

[0056] 2. Isolation and culture of HUVECs

[0057] (1) Take the umbilical cord: Under sterile conditions, take the umbilical cord of the newborn immediately after the cesarean section. ~30cm, after squeezing to remove the residual blood in the umbilical vein, put it into 4°C pre-cooled PBS immediately, and complete the separation of HUVECs within 6 hours.

[0058] (2) Rinse: In the ultra-clean wor...

Embodiment 1

[0109] After mixing 23.5g gastrodin, 8.5g diosgenin, 818g starch, 100g microcrystalline cellulose and 50g sodium carboxymethyl starch, press on a tablet machine to form 5000 tablets, each containing 4.7mg gastrodin , 1.7mg diosgenin.

Embodiment 2

[0111] After mixing 20g gastrodin, 12g diosgenin, 818g starch, 100g microcrystalline cellulose and 50g carboxymethyl starch sodium, press on a tablet machine to form 5000 tablets, each tablet contains 4mg gastrodin, 1mg diosgenin Saponins.

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Abstract

The invention discloses a vascular protection pharmaceutical composition. Active ingredients of the vascular protection pharmaceutical composition are only gastrodin and diosgenin of which the molar ratio is (10-6):(1-4). The invention also discloses another vascular protection pharmaceutical composition which comprises gastrodin and diosgenin of which the molar ratio is (10-6):(1-4), and further discloses application of the vascular protection pharmaceutical composition to preparation of vascular protection pharmaceutical preparations.

Description

technical field [0001] The present invention relates to a blood vessel protection pharmaceutical composition and its use, especially a blood vessel protection medicine composition derived from natural medicinal material extracts and its use. Background technique [0002] Angiogenesis is the process of forming new blood vessels on the basis of existing blood vessels, which often occurs in various diseases such as cancer, dementia, cardiovascular disease, and diabetes. Angiogenesis includes two steps of division and sprouting. Degradation of basement membrane and decreased adhesion of endothelial cells lead to disruption of vascular stability, migration of endothelial cells and proliferation of endothelial stem cells cause vessel sprouting, recruitment of endothelial cells and pericytes leads to the generation of new lumens in the periluminal area, and the gradual formation of mature lumens . Angiogenesis is controlled by an angiogenic switch. Angiogenic switches include an...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61K31/58A61P9/14
CPCA61K31/58A61K31/7034A61K2300/00
Inventor 李志勇叶田园李彦文
Owner MINZU UNIVERSITY OF CHINA