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Vasoprotective pharmaceutical composition and use thereof

A composition and drug technology, applied in the direction of drug combination, cardiovascular system diseases, pharmaceutical formulations, etc., can solve problems such as small quantities

Active Publication Date: 2019-02-26
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with a large number of natural medicinal materials, there are still a small number of relevant reports on natural medicinal extracts as vascular protective agents.

Method used

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  • Vasoprotective pharmaceutical composition and use thereof
  • Vasoprotective pharmaceutical composition and use thereof
  • Vasoprotective pharmaceutical composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051]

[0052] The following describes the isolation and culture process of human umbilical vein endothelial cells HUVEC as test cells.

[0053] 1. Experiment Preparation

[0054] 25cm 2 The cell culture flask was coated with 2% gelatin and kept in a refrigerator at 4°C overnight. Before use, it was placed in a cell culture incubator at 37°C for more than 30 min. After the gelatin was aspirated and discarded, PBS was rinsed three times.

[0055] After sterilizing a 500mL blue-top glass bottle in an autoclave, add 300mL of pre-cooled PBS to transport the umbilical cord.

[0056] 2. Isolation and culture of HUVECs

[0057] (1) Take the umbilical cord: Under sterile conditions, take the neonatal umbilical cord immediately after caesarean section. The surface of the umbilical cord should be white, tender and shiny, and the length of the umbilical cord should be 15 after removing the curved, hematoma, and pinch marks at both ends. ~30cm, after squeezing the residual blood in ...

Embodiment 1

[0109] After mixing 23.5g of gastrodin, 8.5g of diosgenin, 818g of starch, 100g of microcrystalline cellulose and 50g of sodium carboxymethyl starch, compress it on a tablet machine into 5000 tablets, each containing 4.7mg of gastrosin , 1.7mg diosgenin.

Embodiment 2

[0111] After mixing 20g of gastrosin, 12g of diosgenin, 818g of starch, 100g of microcrystalline cellulose and 50g of sodium carboxymethyl starch, compress it into 5000 tablets on a tablet machine, each tablet contains 4mg of gastrosin, 1mg of Dioscorea Saponin.

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Abstract

The invention discloses a vascular protection pharmaceutical composition. Active ingredients of the vascular protection pharmaceutical composition are only gastrodin and diosgenin of which the molar ratio is (10-6):(1-4). The invention also discloses another vascular protection pharmaceutical composition which comprises gastrodin and diosgenin of which the molar ratio is (10-6):(1-4), and further discloses application of the vascular protection pharmaceutical composition to preparation of vascular protection pharmaceutical preparations.

Description

technical field [0001] The present invention relates to a vascular protection pharmaceutical composition and use thereof, in particular to a blood vessel protection pharmaceutical composition derived from natural medicinal material extract and use thereof. Background technique [0002] Angiogenesis is the process of forming new blood vessels on the basis of existing blood vessels, which mostly occurs in cancer, dementia, cardiovascular disease, diabetes and other diseases. Angiogenesis consists of two steps, division and budding. Degradation of the basement membrane and decreased endothelial cell adhesion leads to disruption of vascular stability, endothelial cell migration and endothelial stem cell proliferation lead to vessel sprouting, and the recruitment of endothelial cells and pericytes leads to the formation of new lumen in the periluminal area and the gradual formation of mature lumen . Angiogenesis is controlled by an angiogenic switch. Angiogenesis switches incl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/58A61P9/14
CPCA61K31/58A61K31/7034A61K2300/00
Inventor 李志勇叶田园李彦文
Owner MINZU UNIVERSITY OF CHINA