Sea cucumber enzymatic hydrolysate eyedrops and preparation method thereof

A technology of enzymatic hydrolysis solution and eye drops, which is applied in the direction of medical formula, drug combination, drug delivery, etc., can solve problems such as visual and visual field damage, decreased vision, red eyes, etc., and achieve non-antigenicity, promote absorption, and accelerate Metabolic Effects

Inactive Publication Date: 2016-11-16
DALIAN SHENLAN PEPTIDE TECH R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most eye drops on the market contain substances such as hormones and bacteriostatic agents (preservatives), and long-term use of bacteriostatic (preservative) eye drops will cause dry eyes, causing red eyes, dryness or Pain, and long-term use of too much steroid eye drops can cause steroid glaucoma, leading to vision loss and damage to vision and vision

Method used

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Embodiment

[0037] The present invention provides a kind of preparation method of sea cucumber enzymolysis liquid eye drops, and its mass composition ratio is as follows:

[0038] Pearl powder 3%, borneol 2%, dipotassium glycyrrhizinate 0.2%, sea cucumber enzymatic solution 12%, water 82.8%.

[0039] The production process is as follows:

[0040] Desalinize the sea cucumber with pure water for 8 hours, changing the water every 2 hours;

[0041] Put the desalted sea cucumber into a high-speed chopping machine and mix for 2 minutes. After chopping, put it into a colloid mill for grinding;

[0042] Mix the ground sea cucumber slurry with water at a mass ratio of 1:7.5, adjust the temperature to 48°C, and adjust the pH to 7 with a 10% NaOH solution;

[0043] Add compound protease, the amount of enzyme added is 2.5% of the protein content of sea cucumbers fed into the feed, stirring continuously during enzymolysis, the temperature of the enzymolysis system is maintained at 48 ° C, and the ti...

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Abstract

The invention provides sea cucumber enzymatic hydrolysate eyedrops which comprise 1 to 5 percent of pearl powder, 2 to 4 percent of borneol, 0.1 to 0.5 percent of dipotassium glycyrrhizinate, 8 to 15 percent of a sea cucumber enzymatic hydrolysate and 76 to 85 percent of water for injection. The invention also provides a preparation method of the sea cucumber enzymatic hydrolysate eyedrops. The preparation method comprises the following steps: taking desalted sea cucumber, and conducting chopping and grinding; adding compound protease for enzymolysis; conducting centrifugation and collecting centrifugal clear liquid; conducting electrodialysis treatment and nanofiltration membrane concentration treatment to obtain a concentrate of which the content of soluble solid material is 20-40 Brix, namely the sea cucumber enzymatic hydrolysate; adding the pearl powder,the borneol powder and dipotassium glycyrrhizinate according to ratio; conducting uniform stirring, filtering and centrifugation; conducting disinfection so as to obtain the sea cucumber enzymatic hydrolysate eyedrops. The sea cucumber enzymatic hydrolysate eyedrops prepared by the method have the capabilities of relieving eye fatigue and ache, resisting radiation, moisturizing, relieving eye dryness, eliminating inflammation and resisting bacteria, and has certain effects on relieving symptoms of eye visual fatigue, eye dryness, eyestrain and the like.

Description

technical field [0001] The invention relates to an eye drop and a preparation method, in particular to a sea cucumber enzymatic hydrolysis liquid eye drop and a preparation method. Background technique [0002] Sea cucumber is as famous as ginseng, bird's nest and shark's fin, and is one of the eight treasures in the world. Sea cucumber is not only a precious food, but also a valuable medicinal material. According to the records in "Compendium of Materia Medica": Sea cucumbers are sweet and salty, tonify the kidneys, benefit the essence, take urine, aphrodisiac and treat impotence. [0003] Sea cucumber enzymatic hydrolysis solution is obtained by enzymatic hydrolysis of sea cucumbers. Through enzymatic hydrolysis, sea cucumbers are enzymatically hydrolyzed into nano-scale sea cucumber polysaccharides, sea cucumber small peptides, and sea cucumber saponins, which are easy to absorb. There are two main types of sea cucumber polysaccharides: one is sea cucumber glycosaminogl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/618A61K9/08A61P27/02A61K31/045A61K31/704A61K35/616
CPCA61K35/618A61K9/0048A61K9/08A61K31/045A61K31/704A61K35/616A61K2300/00
Inventor 包卫洋詹龙全王祖哲张莹
Owner DALIAN SHENLAN PEPTIDE TECH R & D CO LTD
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