Anti-glioma active substance streptodepsipeptide P11B, preparation and applications thereof

A technology of streptomycin and glioma, applied in the field of medicine, can solve the problems of limited curative effect, drug resistance, large toxic and side effects, etc.

Active Publication Date: 2016-11-30
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, there is a serious shortage of anti-glioma drugs in the world. Temozolomide is currently the only first-line drug that can be used alone for the treatment of glioma in clinical practice. Moreover, the curative effect of existing drugs for the treatment of glioma, including Temozolomide, is limited. Insufficient, the outstanding performances are: (1) most of them are chemicals with high toxicity and side effects; (2) severe drug resistance of tumor cells to drugs; (3) blood-brain barrier prevents drugs from reaching the brain and exerting their curative effect

Method used

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  • Anti-glioma active substance streptodepsipeptide P11B, preparation and applications thereof
  • Anti-glioma active substance streptodepsipeptide P11B, preparation and applications thereof
  • Anti-glioma active substance streptodepsipeptide P11B, preparation and applications thereof

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Embodiment Construction

[0029] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. However, the present invention is not limited to these Examples.

[0030] 1. Isolation and cultivation of Streptomyces parvulus P11-23B

[0031] Take 1 gram of air-dried sea mud and dilute it with seawater to a concentration of 1×10 -6 g / mL sample diluent, take 200 μL of sample diluent and evenly disperse it in a petri dish containing Gause’s agar solid medium, and after culturing at 28°C for 7 days, transfer different colonies separately Transfer to another Petri dish containing Gore's agar solid medium, and continue culturing at 28°C for 7 days. Finally, a well-grown single colony (P11-23B) was inoculated on the slant medium of Gowell's agar for culture, and then stored in a 4°C refrigerator for later use.

[0032] 2. Identification of Streptomyces parvulus P11-23B

[0033] The species of the obtained strain P11-23B was identified by 16S r...

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Abstract

The invention provides a compound streptodepsipeptide P11B having anti-glioma activity, wherein the streptodepsipeptide P11B is a marine natural active substance, and is obtained by carrying out separation culture purification in Streptomyces parvulus P11-23B. According to the present invention, the test results prove that the streptodepsipeptide P11B can significantly inhibit the proliferation of a variety of glioma cells, and can be used in preparation of drugs for glioma treatment, wherein the drugs comprise the separate streptodepsipeptide P11B active component and a pharmaceutically acceptable carrier, or the streptodepsipeptide P11B active component, other drugs or effective components, and a pharmaceutically acceptable carrier; the anti-glioma activity of the compound is firstly discovered, and the new way is provided for the preparation of the anti-glioma drug; and the chemical structure formula of the streptodepsipeptide P11B is defined in the specification.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an anti-tumor active compound streptomycin P11B (streptodepsipiptide P11B) and the application of the compound in the preparation of medicaments for treating brain glioma. Background technique [0002] Glioma is the most common and malignant brain tumor in the brain, accounting for 70% of all malignant brain tumors. Due to the special location of glioma, it involves many important brain functional areas, which makes the clinical operation difficult and it is not easy to completely remove the tumor, so the treatment of glioma is particularly important. However, there is a serious shortage of anti-glioma drugs in the world. Temozolomide is currently the only first-line drug that can be used alone for the treatment of glioma in clinical practice. Moreover, the curative effect of existing drugs for the treatment of glioma, including Temozolomide, is limited. Insufficient, the prominent perform...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K11/02C12P21/04C12N1/20A61K38/15A61P35/00C12R1/465
CPCA61K38/00C07K11/02C12P21/02C12N1/205C12R2001/465
Inventor 张治针叶雪威连晓媛
Owner ZHEJIANG UNIV
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