Wound treatment material

A wound and fiber technology, applied in the fiber field, can solve the problems of insufficient fiber absorption, no antibacterial performance, harsh reaction conditions, etc., achieve good liquid absorption performance and antibacterial performance, maintain moderate humidity environment, and mild reaction conditions Effect

Active Publication Date: 2016-12-14
JIANGSU NEWVALUE MEDICAL PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these modification methods, on the one hand, have harsh reaction conditions, cumbersome steps, and are not easy to control; on the other hand, the distribution position and quantity of substituents on the molecular chain of the product obtained from the reaction are uncertain, making it difficult to effectively control the liquid absorption performance of the product.
In addition, the above products do not have antimicrobial properties either
These problems will greatly limit the clinical application of dressings prepared from chitin fibers, especially in the treatment of burns and chronic wounds.
[0005] In particular, in the past chitin fibers, people often control the liquid absorption performance of the fiber by controlling the degree of substitution, but the inventors of the present invention found that if the substitution is too low, the liquid absorption of the fiber is insufficient, and if the substitution is too high, Although the liquid absorption is significantly increased, the fiber shape is difficult to maintain, that is, the fibers will be dissolved or dispersed by the absorbed liquid
At this time, the outflow of liquid will cause a certain degree of loss of suction function.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Weigh 5 g of chitin fibers with a length of 6 cm and a p / (m+n+p) of 0.25, disperse them in 50 mL of isopropanol, add 2.54 g of 2-hydroxyethyl acrylate, and shake evenly at room temperature. React in a constant temperature water bath for 48 hours under the same conditions, separate the reacted chitin fibers from the reaction mixture, wash twice with 80% (v / v) methanol aqueous solution, take out the fibers, dry them, and disperse them in 80% (v / v) v) Add 30% (w / v) potassium hydroxide aqueous solution dropwise to methanol aqueous solution, adjust the pH of methanol and potassium hydroxide aqueous solution mixture to 11.0, soak for 1 hour, and then separate the soaked fiber from the mixture , washed 3 times with 80% (v / v) methanol aqueous solution, dehydrated, and dried at 40°C to obtain a liquid-absorbent fiber with a viscosity-average molecular weight (Mη) of 3 million and a degree of substitution of acryl group total substance of 0.17.

[0116] Dissolve absorbent fibers ...

Embodiment 2

[0118] Weigh 5 g of chitin fibers with a length of 6 cm and a p / (m+n+p) of 0.10, disperse them in 50 mL of isopropanol, add 7.09 g of 2-hydroxypropyl acrylate, and shake evenly at room temperature. React in a constant temperature water bath for 48 hours under the same conditions, separate the reacted chitin fibers from the reaction mixture, wash twice with 80% (v / v) methanol aqueous solution, take out the fibers, dry them, and disperse them in 80% (v / v) v) Add 30% (w / v) potassium hydroxide aqueous solution dropwise to methanol aqueous solution, adjust the pH of methanol and potassium hydroxide aqueous solution mixture to 11.0, soak for 1 hour, and then separate the soaked fiber from the mixture , washed three times with 80% (v / v) methanol aqueous solution, dehydrated, and dried at 40°C to obtain a liquid-absorbent fiber with a viscosity-average molecular weight of 3 million and a degree of substitution of acryl group total substance of 0.30.

[0119] Dissolve absorbent fibers ...

Embodiment 3

[0121] Weigh 5 g of chitin fibers with a length of 6 cm and a p / (m+n+p) of 0.10, disperse them in 50 mL of isopropanol, add 14.17 g of 2-hydroxypropyl acrylate, and shake evenly at room temperature. React in a constant temperature water bath for 48 hours under the same conditions, separate the reacted chitin fibers from the reaction mixture, wash twice with 80% (v / v) methanol aqueous solution, take out the fibers, dry them, and disperse them in 80% (v / v) v) Add 30% (w / v) potassium hydroxide aqueous solution dropwise to methanol aqueous solution, adjust the pH of methanol and potassium hydroxide aqueous solution mixture to 11.5, soak for 1 hour, and then separate the soaked fiber from the mixture , shake dry, and place in saturated CaCl 2 Soak in the solution for 1 hour, take out the fiber, wash 3 times with 80% (v / v) methanol aqueous solution, and dry at 40°C after dehydration to obtain a viscosity-average molecular weight of 500,000 and a total substitution degree of acryloyl...

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Abstract

The invention discloses a wound treatment material which comprises a fiber. The wound treatment material is characterized in that the fiber comprises a polymer shown as the following structural formula (please see the formula in the description), wherein R is at least one selected from a group composed of -NH2, -OCH2CH2OH, -OCH2CH2CH2OH, -OH, -ONa, -OK and -OCa, m, n and p represent the quantity percentages of corresponding repetitive units in a polymer molecule respectively and meet the following relational expressions that m+n+p=1 and p/(m+n+p)=0.05-0.30, the substitution degree D is defined to be equal to m/(m+n+p), the overall substitution degree of the fiber is defined as Ds, the substitution degree of the polymer at the center point of the cross section of the fiber is defined as Do, the substitution degree of the polymer at the edge of the cross section of the fiber is defined as Dx, and Ds, Do and Dx meet the following relational expressions that Ds=0.09-0.8 and Do/Dx=0-0.7.

Description

technical field [0001] The present invention relates to a fiber, in particular to a fiber which can absorb liquid by swelling. Background technique [0002] Chitin has good biocompatibility, biodegradability, hemostasis, and promotion of wound healing, making it suitable for various tissue engineering scaffold materials such as absorbable surgical sutures, wound dressings, drug carrier materials, and artificial skin has broad application prospects. [0003] Chitin is dissolved in organic acid or inorganic acid to form a viscous colloid. After spinning, coagulation, washing, drying and other processes, chitin fibers can be obtained, which can be used to prepare wound dressings. Chinese patent document CN1129748A (deacetylated chitosan fiber and its manufacturing method and application), Chinese patent document CN1149093A (chitin fiber and its preparation method), Chinese patent document CN101250759A (medical chitosan fiber and its preparation method) etc. Manufacturing meth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/46A61L24/08D06M14/02
CPCA61L15/28A61L15/46A61L24/0015A61L24/08A61L2300/232A61L2300/404A61L2400/04D06M14/02C08L5/08
Inventor 周应山杨柳清徐灿红蒋锐龚祖光王立平
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD
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