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A kind of separation and extraction method of food grade niacin

An extraction method, food-grade technology, applied in the field of preparation and extraction, preparation and extraction of food-grade niacin, can solve the problems of difficult acid wastewater treatment, high equipment investment cost, long extraction cycle, etc., to reduce the discharge of highly polluted wastewater , low production cost and easy operation

Active Publication Date: 2019-06-25
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method has complex process, long extraction cycle, difficult acid wastewater treatment, high equipment investment cost and relatively low yield

Method used

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  • A kind of separation and extraction method of food grade niacin

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Comparison scheme
Effect test

Embodiment 1

[0016] After the niacin biotransformation reaction is completed, take 100L of niacin conversion solution, the conversion acid production rate is 150g / L, and pump the conversion solution into the filter area with a filter area of ​​1m 2 , A ceramic membrane filter with a pore size of 50nm is used for filtration, the temperature is controlled at 30°C, the pressure difference between the membrane inlet and outlet pressure is 0.25MPa, and the filtration rate is 20L / h. When the remaining feed liquid is 25L, continuously add purified water for top washing to maintain Continue to filter at a liquid level of 15 L until the nicotinic acid content in the dope is less than 1.5 g / L and stop filtering to obtain 160 L of nicotinic acid membrane filtrate with a content of 93.7 g / L and a membrane-passing yield of nicotinic acid of 99.5%. Put 90L of D201 perforated adsorption resin into a φ40cm×150cm resin column, use 50% ethanol solution, flow rate 40L / h, when 100L is introduced, soak for 4h, ...

Embodiment 2

[0018] After the niacin biotransformation reaction is completed, take 200L of niacin conversion solution, the conversion acid production rate is 150g / L, and pump the conversion solution into the filter area with a filter area of ​​2m 2 , A ceramic membrane filter with a pore size of 50nm is used for filtration, the temperature is controlled at 30°C, the pressure difference between the membrane inlet and outlet pressure is 0.25MPa, and the filtration rate is 20L / h. When the remaining feed liquid is 25L, continuously add purified water for top washing to maintain Continue filtering at a liquid level of 15 L until the nicotinic acid content in the dope is below 1.5 g / L and stop filtering to obtain 280 L of nicotinic acid membrane filtrate with a content of 106.4 g / L and a membrane yield of niacin of 99.3%. Put 140L of D201 perforated adsorption resin into a φ40cm×150cm resin column, regenerate the resin, and filter 280L of the filtrate obtained by ceramic membrane for adsorption o...

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Abstract

The invention discloses a method for separating and extracting food-grade nicotinic acid on the basis of biotransformation. The method comprises the steps that transformation liquid is filtered by a ceramic membrane or plate frame to remove thalli, a treated nicotinic acid solution is adsorbed by macroporous resin, eluted, concentrated, crystallized and dried, and finished nicotinic acid is obtained. First-time crystallization mother liquid needs to be recycled to increase the yield of nicotinic acid. According to the method, technological operation is easy, energy conversation and environment protection are achieved, and continuous production can be achieved. The total yield of nicotinic acid extraction can reach 90% or above, and the product quality meets the national standard.

Description

technical field [0001] The invention belongs to the field of biochemical industry and relates to a preparation and extraction method, in particular to a method for preparing and extracting food-grade niacin from fermentation broth. Background technique [0002] Nicotinic acid (Nicotinic acid) chemical name is pyridine-3-carboxylic acid, commonly known as nicotinic acid, vitamin PP or vitamin B3, is one of the 13 kinds of vitamins necessary for the human body, its molecular formula is C6H5NO2, molecular weight is 123.11, melting point is 236°C, easy Soluble in boiling water, boiling ethanol, alkali hydroxide and carbonate alkali solution, soluble in propylene glycol, insoluble in ether, its structural formula is as follows figure 1 . [0003] The human body’s daily requirement for niacin is: 10-20 mg for adults and 4-11 mg for infants (Li Yanyun, Journal of Beijing Institute of Petrochemical Technology, 2006, 14:59-64). At the same time, niacin is also an essential ingredie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/80C07D213/803
CPCC07D213/80C07D213/803
Inventor 许正宏史劲松龚劲松窦文芳张强
Owner JIANGNAN UNIV