Novel antibody prepared by coupling micromolecular immunity agonist and PD-1 antibody and application of antibody in tumor resistance

An agonist, small molecule technology, applied in the field of immunochemistry, can solve the problem of low efficacy ratio of PD-1 antibody

Pending Publication Date: 2017-01-04
SHENZHEN UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a new type of antibody coupled with a small molecule immun...

Method used

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  • Novel antibody prepared by coupling micromolecular immunity agonist and PD-1 antibody and application of antibody in tumor resistance
  • Novel antibody prepared by coupling micromolecular immunity agonist and PD-1 antibody and application of antibody in tumor resistance
  • Novel antibody prepared by coupling micromolecular immunity agonist and PD-1 antibody and application of antibody in tumor resistance

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Embodiment Construction

[0042] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0043] The present invention provides a novel antibody coupled with a small molecule immune stimulant to PD-1 antibody, which has the following general structural formula [I]:

[0044]

[0045] In formula [Ⅰ]: X 1 Represents OH or SH; R 1 Represents an alkoxy or alkylamine group, X 2 Indicates a linking group; wherein the antibody and the small molecule immune agonist are formed by covalently linking the small molecule immune agonist and the antibody, and m is the number of small molecule agonists (m is defined as the degree of coupling), which is 1 The number of ~10; the antibody part refers...

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Abstract

The invention provides a novel antibody prepared by coupling a micromolecular immunity agonist and a PD-1 antibody and application thereof. The novel antibody is obtained through coupled reaction of the micromolecular immunity agonist and the PD-1 antibody and comprises a compound shown as the following formula [I] (shown in the description). The novel antibody can be used for immunotherapy and immune regulation of malignant tumors.

Description

technical field [0001] The present invention relates to the field of immunochemistry, and more specifically, relates to a PD-1 antibody that has an inhibitory effect on the immune system and a class of small molecule immune agonists to form a novel antibody, as well as the preparation and application of the novel antibody in the anti-immune system. applications in tumors. Background technique [0002] In recent years, an important progress in the field of immune anti-tumor is the application of anti-tumor immunity of PD-1 antibody. As a breakthrough antibody drug against tumors, its target is expressed on immune cells (such as T cells) PD-1 protein. PD-1 is an immunosuppressive protein, which can suppress and balance the immune system of normal human body. However, in tumor patients, PD-1 also inhibits the normal anti-tumor immune response; therefore, PD-1 antibodies can relieve this immunosuppressive effect on tumors (Chinese Journal of Biological Products, June 2014, Vol...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P35/00A61P31/12A61P37/02A61P3/10C07K16/28A61K31/52C07D473/18
CPCA61K31/52A61K39/395A61P35/00A61P37/02C07K16/28A61K39/39558C07D473/18C07K16/2803A61K2300/00
Inventor 靳广毅王竹林
Owner SHENZHEN UNIV
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