Application of cinnamon aldehyde in the preparation of drugs for targeted treatment of drug-resistant candida infection
A technology of candida and cinnamaldehyde, applied in the field of medicine, can solve the problems of difficult clinical treatment and poor prognosis
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Embodiment 2
[0043] Embodiment 2 Cinnamaldehyde monomer clathrate of the present invention
[0044] Composition: Cinnamaldehyde 1.25g (50 parts by weight)
[0045] 2-hydroxypropyl-β-cyclodextrin 1.25g (50 parts by weight)
[0046] Preparation:
[0047] 1) Add 2-hydroxypropyl-β-cyclodextrin into deionized distilled water at 90°C, stir to dissolve, then cool down to 20°C to prepare an aqueous solution for later use; among them, 2-hydroxypropyl-β-cyclodextrin The weight mg / volume mL ratio of essence and deionized distilled water is 1:8;
[0048] 2) Under stirring, slowly add cinnamon aldehyde dissolved in ethyl acetate dropwise to the aqueous solution obtained in step 1). After the dropwise addition, raise the temperature to 70°C and continue stirring for 1 hour, then refrigerate for 24 hours to obtain a refrigerated solution , standby; wherein, the volume mL ratio of cinnamaldehyde to ethyl acetate is 1:6;
[0049] 3) Filter the refrigerated liquid obtained in step 2), wash the solid mat...
Embodiment 3
[0050] Embodiment 3 Cinnamaldehyde monomer clathrate of the present invention
[0051] Composition: Cinnamaldehyde 1g (10 parts by weight)
[0052] 2-hydroxypropyl-β-cyclodextrin 2g (20 parts by weight)
[0053] Preparation method: with embodiment 2.
Embodiment 4
[0054] Embodiment 4 Cinnamaldehyde monomer clathrate of the present invention
[0055] Composition: Cinnamaldehyde 6g (60 parts by weight)
[0056] 2-hydroxypropyl-β-cyclodextrin 8g (80 parts by weight)
[0057] Preparation method: with embodiment 2.
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