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A Dynamic Imaging Method of Lung Hyperpolarized Gas Based on Variable Sampling Rate

A dynamic imaging, variable sampling rate technology, applied in 2D image generation, image generation, image data processing and other directions, can solve the problems of low signal-to-noise ratio of magnetic resonance images, the influence of lung motion artifacts, and slow MRI speed.

Active Publication Date: 2018-12-25
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Abstract
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Problems solved by technology

[0005] However, hyperpolarized 129 The polarizability of Xe decays exponentially with the increase of excitation times and excitation time, resulting in low signal-to-noise ratio of magnetic resonance images
In addition, MRI is slow compared to other imaging modalities, resulting in reduced temporal resolution of MR images and susceptibility to lung motion artifacts

Method used

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  • A Dynamic Imaging Method of Lung Hyperpolarized Gas Based on Variable Sampling Rate
  • A Dynamic Imaging Method of Lung Hyperpolarized Gas Based on Variable Sampling Rate
  • A Dynamic Imaging Method of Lung Hyperpolarized Gas Based on Variable Sampling Rate

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Experimental program
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Embodiment 1

[0046] Step 1. During the inspiratory dynamic imaging of the lungs using fixed-angle excitation, set the average polarization M of the hyperpolarized gas in the lungs p The function that changes with time t is M p (t), the average signal intensity of the hyperpolarized gas in the lung can be used M p (t) means, M p (t) is:

[0047]

[0048] Among them, TR is the repetition time, the setting range is 10-20ms, and it is set to 10ms in this experiment. FA c is the initial excitation angle for fixed-angle excitation, and the setting range is 5-9°. In this experiment, it is set to 5°. According to formula (1), M p (t) curve, such as figure 2 shown.

[0049] Step 2, according to the initial polarization and volume of the hyperpolarized gas to be inhaled into the lungs, set M p (t) the first threshold TH 1 ,Such as figure 2 As shown, different imaging parameters are adopted before and after the first threshold TH1. When M p (t) ≥ first threshold TH 1 When , the fixed-a...

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Abstract

The invention discloses a lung hyperpolarized gas dynamic imaging method based on a variable sampling rate, comprising the steps of optimizing magnetic resonance imaging data firstly, including data collection rate, motivate angle, sampling time and the like; confirming the sampling track and phase encoding method, carrying out lung inspiration dynamic imaging, obtaining K-space data; constructing the corresponding target function by the feature of lung inspiration dynamic imaging, reconstructing the lung hyperpolarized gas magnetic resonance image by the function, and the method can obtain high signal-to-noise ratio lung dynamic inspiration magnetic resonance image with higher temporal-spatial resolution.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging (MRI) technology of the lung, low-rank and compressed sensing theory, and in particular to a dynamic imaging method of lung hyperpolarized gas based on variable sampling rate. Background technique [0002] With the increasing air pollution in our country, lung disease has become a major threat to life safety. Many lung diseases, such as lung cancer and chronic obstructive pulmonary disease (Chronic Obstructive Pulmonary Disease, COPD), are usually discovered at an advanced stage and are difficult to cure. Therefore, there is an urgent need for a safe lung imaging that can diagnose lung diseases early learning method. [0003] Commonly used medical imaging methods such as computerized tomography (Computed Tomography, CT) and positron emission computed tomography (PET) are radioactive, so it is not advisable to do more in a short period of time. Although traditional MRI methods ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T11/00A61B5/055
CPCA61B5/004A61B5/055G06T11/00G06T2210/41
Inventor 周欣肖洒邓鹤孙献平叶朝辉
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI