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Drug composition for improving safety of compound ginseng injection

A composition and injection technology, applied in the field of medicine, can solve the problems of pH value drop of solution, easy rancidity of polysorbate 80, accelerated pH value of liquid medicine, etc., achieve high dosage, improve safety and good effect of safety

Inactive Publication Date: 2017-02-01
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Drug composition for improving safety of compound ginseng injection
  • Drug composition for improving safety of compound ginseng injection
  • Drug composition for improving safety of compound ginseng injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016]

[0017] Preparation method: ginseng and Dan are decocted twice in water for 2 hours each time, combined with decoction, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.27-1.30 (80°C), let cool, and ethanol is added to make the ethanol content It was 65%, left standing overnight, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.30 (80 ° C), 3 times the amount of water was added, fully stirred, refrigerated for 48 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65%. The density is about 1.15 (80°C), and the medicinal liquid is used for later use; add water to decoction for two times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 to 1.30 (80°C), and let it cool. , add ethanol to make the ethanol content be 65%, let stand overnight, filter, concentrate th...

Embodiment 2

[0019]

[0020] Preparation method: ginseng and Dan are decocted twice in water for 2 hours each time, combined with decoction, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.27-1.30 (80°C), let cool, and ethanol is added to make the ethanol content It was 65%, left standing overnight, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.30 (80 ° C), 3 times the amount of water was added, fully stirred, refrigerated for 48 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65%. The density is about 1.15 (80°C), and the medicinal liquid is used for later use; add water to decoction for two times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 to 1.30 (80°C), and let it cool. , add ethanol to make the ethanol content be 65%, let stand overnight, filter, concentrate the filtrate u...

Embodiment 3

[0022]

[0023] Preparation method: ginseng and Dan are decocted twice in water for 2 hours each time, combined with decoction, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.27-1.30 (80°C), let cool, and ethanol is added to make the ethanol content It was 65%, left standing overnight, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.30 (80 ° C), 3 times the amount of water was added, fully stirred, refrigerated for 48 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65%. The density is about 1.15 (80°C), and the medicinal liquid is used for later use; add water to decoction for two times, 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 to 1.30 (80°C), and let it cool. , add ethanol to make the ethanol content be 65%, let stand overnight, filter, concentrate the filtrate u...

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PUM

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Abstract

This invention discloses a drug composition for improving the safety of a compound ginseng injection. The drug composition for injection is mainly prepared from a ginseng extract, salvia miltiorrhiza extract, a euphorbia humifusa extract and polyoxyl 15 hydroxystearate. A cosolvent good in safety and obvious in solubilizing-aiding effect is adopted to replace a cosolvent polysorbate 80 having potential safety hazard and affecting the product quality existing in the compound ginseng injection, the safety of the polyoxyl 15 hydroxystearate is higher than that of the polysorbate 80, the usage amount of the polyoxyl 15 hydroxystearate is lower, the probability and risk of adverse reaction of drugs are reduced, and the safety of clinical medication is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for improving the safety of compound ginseng injection. Background technique [0002] The standard of compound ginseng injection is included in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine). It has the effect of promoting blood circulation, removing blood stasis and relieving pain. Clinically used for the treatment of dysmenorrhea, amenorrhea, fall injury, rheumatic arthralgia and so on. [0003] Compound ginseng injection has been widely used in clinic for many years in my country, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditional Chinese medicine injections have become increasingly serious, affecting the development of traditional Chinese medicine injections w...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K47/14A61K9/08A61K9/19A61P15/00A61P29/00
CPCA61K36/258A61K9/0019A61K9/08A61K9/19A61K36/47A61K36/537A61K47/14A61K2300/00
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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