A composite surface drug-loaded slow-release system and its preparation method

Abstract

The invention discloses a composite surface drug-carrying slow-release system and a preparation method thereof. The composite surface drug-carrying slow-release system comprises a drug carrying matrix, wherein the surface of the drug carrying matrix has a nanotube structure and a micron pore pit structure; nanotubes, tube clearances and micron pore pit drug storage spaces are formed on the surface of the drug carrying matrix; and drugs are carried in the nanotubes, tube clearances and micron pore pit drug storage spaces. The drug-carrying matrix surface of the drug-carrying slow-release system is provided with the nanotubes, tube clearances, micron pore pits and many other different drug storage regions, thereby ensuring the early-stage drug release concentration and prolonging the drug release duration. The preparation method of the drug-carrying slow-release system combines alkali fusion and anode oxidation to obtain the composite surface with the sequence nanotube structure and micron hole pit structure; and the obtained micron hole pits are relatively flat and provide advantages for the formation of the subsequent sequence nanotube structure.

Description

technical field [0001] The invention relates to the technical field of drug sustained release, in particular to a composite surface drug-loaded sustained release system suitable for fixed-point release therapy and a preparation method thereof. Background technique [0002] Spinal tuberculosis takes the first place in bone and joint tuberculosis of the whole body, among which tuberculosis of the vertebral body accounts for the majority, and tuberculosis of the appendages is very rare. In the entire spine, the lumbar spine has the largest range of motion and the highest incidence of tuberculosis in the lumbar spine, followed by the thoracic spine, followed by the cervical spine. As for sacral and coccyx tuberculosis, it is very rare. The treatment of spinal tuberculosis is relatively cumbersome, and the decision whether to perform surgery is based on whether there are indications for surgery. Even for those with indications for surgery, 2-4 weeks of non-surgical treatment is ...

AI Technical Summary

Problems solved by technology

Anodizing can obtain a drug-loaded matrix with a surface sequence tube structure, forming a huge storage space on the surface, which provides the possibility for drug loading and sustained release. Compared with rough surfaces, this surface tube structure has a higher release time. A certain improvement but still not enough to meet the 3 months required for sterilization

In this regard, some scholars add a layer of slow-release layer on the surface after loading the drug on the oxidized surface. The existence of the slow-release layer greatly slows down the release rate of the drug in the tube, so that the release time can reach about 1 month, but this is different from expectations. There is still a certain distance between the length of time, and the addition of the coating may block the contact between osteoblasts and the oxidized surface, prolong the fixation time and even cause the titanium nail to be implanted unstable and loose

On the other hand, in the initial stage of treatment, a large amount of drug release is needed to play a bactericidal effect. Therefore, the thickness of the slow-release layer needs to be controlled within a certain range. If the slow-release layer is too thick, it will affect the early drug release in large quantities. If the release layer is too thin, the release time of the drug cannot be guaranteed

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