Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination

一种髓鞘、功能障碍的技术，应用在代谢疾病、感觉疾病、肌肉系统疾病等方向，能够解决少再生能力等问题

Inactive Publication Date: 2017-02-08
CLENE NANOMEDICINE INC A NEVADA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Researchers once thought that CNS neurons simply had less inherent regenerative capacity, but this paradigm was challenged by the discovery that CNS neurons could be grown by peripheral nerve grafts

Method used

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  • Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination
  • Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination
  • Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Fabrication of gold nanosuspension "CNM-Au8" for object therapy

[0116] In general, the CNM-Au8 nanosuspensions used for therapeutic purposes in Examples 2 and 3 were concentrated CNM-Au8 "pure" nanosuspensions, i.e., using figure 1 , 2C Pure product produced by certain embodiments of the invention associated with the apparatus shown generally in 3. All of the trough members 30a' and 30b' in the above figures were made of 1 / 8" (about 3 mm) thick plexiglass and 1 / 4" (about 6 mm) thick polycarbonate, respectively. Support structure 34 (not shown in many figures, but in figure 1 shown in ) is also made of plexiglass and is about 1 / 4" thick (about 6-7mm thick). Each trough member 30a' is integrated with a trough member 30b'. The trough members 30a' described herein The cross-sectional shape corresponds to Figure 4B The shape shown in (ie trapezoidal cross-section). The relevant dimensions for the 30a' are: "S,S'" is about 1.5" (about 3.81cm), "M" is about 2.5" (about...

Embodiment 2

[0215] Cuprizone demyelination model - a preliminary study in 16 mice

[0216] The purpose of this pilot study was to determine whether a suspension of "CNM-Au8" nanocrystals concentrated to 51 ppm and consumed ad libitum could affect the myelin damage (or repair) amount or degree. The Cuprizone mouse model is designed to mimic myelin damage in mammals caused by a variety of diseases that manifest themselves pathologically as demyelination or dysmyelination.

[0217] As shown in Table 2, a total of 16 C57BL6 male mice were divided into 4 groups (4 mice each). Two additional mice were used as backups and they were not required in this study. Mice were 8 weeks old at the start of the study.

[0218] In an attempt to induce demyelination by introducing toxic cuprizone and to observe reduction of demyelination and / or promotion of remyelination possibly caused by treatment with gold nanosuspension, two of the four groups Groups were fed Cuprizone chow for 5 weeks. As shown in ...

Embodiment 3

[0274] Cuprizone demyelination model - 2 weeks / 5 weeks - study of 105 mice

[0275] overview

[0276] The purpose of this 105-mice study was to determine (1) a gold concentration of approximately 50 ppm as an ad libitum treatment from a water bottle (as the mice's only drinking fluid for the last 3 or all 5 weeks of the study) or ( 2) Treatment by gavage (for the last 3 weeks or all 5 weeks in the study) at a gold concentration of approximately 1000 ppm (and once daily in a volume of approximately 10 mL of CNM-Au8 nanosuspension / kg based on the body weight of each mouse) Whether the "CNM-Au8" nanosuspension given to the mice with a body weight of "10mL / kg" by gavage) can act as a therapeutically or prophylactically effective dose and thus affect the myelin damage present in the corpus callosum and / or promote remyelination of at least some axons in the corpus callosum. As in Example 2, myelin damage was induced by mice ingesting Cuprizone feed.

[0277] As shown in Table 3...

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Abstract

The invention relates to methods and compositions for treating demyelination and / or dysmyelination and / or promoting remyelination of neurons and / or preventing the development of myelin-related diseases by administering to a subject in need thereof an effective amount (either therapeutic or prophylactic) of an elemental gold crystal nanosuspension.

Description

technical field [0001] The present invention involves the administration of elemental gold nanosuspensions, and in preferred embodiments the surface-cleaning gold-based nanocrystal suspensions disclosed herein, to a subject in need thereof in an effective amount and concentration (therapeutically or prophylactically) to Methods and compositions for treating the causes of neuronal dysmyelination and / or demyelination and / or preventing the occurrence of myelin and axon-related diseases and / or promoting remyelination. Background technique [0002] A demyelinating disease is any disease in which the myelin sheath of neurons in the central nervous system ("CNS") and / or peripheral nervous system ("PNS") becomes damaged. Damage to the myelin sheath often adversely affects the conduction of signals in the affected nerve, and / or causes some type of abnormal or reduced performance of the underlying neurons. Depending on which neurons / myelin sheaths are damaged or abnormal, the associa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K9/14A61K33/242
CPCA61K9/14A61K9/10A61K9/16A61P21/04A61P25/00A61P25/02A61P25/04A61P25/28A61P27/02A61P3/06A61P43/00A61K33/242A61K33/24A61K47/02B82Y5/00A61K9/0019A61K9/0085A61K41/0023
Inventor 张仲衍马克·G·莫藤森
Owner CLENE NANOMEDICINE INC A NEVADA CORP
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