Method for producing 2-(N-methyl chloride acetamido)-5-chlorobenzophenone

A technology of methyl chloroacetamido and chlorobenzophenone, applied in the production field of chemical substances, can solve the problems such as low production rate, waste of production cost, etc., and achieves the advantages of simple and clear method, improved product volume, and production cost saving. Effect

Inactive Publication Date: 2017-02-15
枣阳凤泽环化科技有限公司
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  • Abstract
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  • Claims
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Problems solved by technology

[0003] The technical problem to be solved by the embodiments of the present invention is that, aiming at the low production rate of the existing 2-(N-methylchloroacetamido)-5-chlorobenzophenone and the waste of production costs, a production method is proposed. Method for 2-(N-methylchloroacetamido)-5-chlorobenzophenone

Method used

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  • Method for producing 2-(N-methyl chloride acetamido)-5-chlorobenzophenone

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Embodiment Construction

[0009] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0010] See figure 1 , figure 1 It is a flowchart of the method for producing 2-(N-methylchloroacetamido)-5-chlorobenzophenone according to the first embodiment of the present invention. In this embodiment, the method for producing 2-(N-methylchloroacetamido)-5-chlorobenzophenone comprises:

[0011] In step S11, put 259.8 parts by weight of toluene and 120 parts by weight of isoxazole into the reactor and raise the temperature to 110 degrees Celsius;

[0012...

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Abstract

An embodiment of the invention discloses a method for producing 2-(N-methyl chloride acetamido)-5-chlorobenzophenone. The production method comprises the following steps: 259.8 parts by weight of toluene and 120 parts by weight of isoxazole are added into a reaction vessel, the vessel is heated to 110 DEG C; the vessel is cooled to 90 DEG C and 130 parts by weight of dimethyl ester; the temperature is controlled at 90-100 DEG C and the temperature is kept for 2.5 hours; 500 parts by weight of water is added, and materials are distributed to a reduction kettle; 259.8 parts by weight of toluene and 75 parts by weight of iron powder are added into the reduction kettle, heating, reflowing and reaction are carried out for 3 hours, the materials are permitted to stand and water is separated, filtering is carried out to a crystallization kettle, and the temperature is cooled to 10 DEG C, and filtering and centrifugation are carried out; the centrifugal materials are poured into a reaction vessel, and the reaction vessel is heated to 110 DEG C; the temperature is cooled to 45 DEG C, 120 parts by weight of chloroacetyl chloride is added dropwisely, and the temperature is heated to 90 DEG C; the temperature is controlled at 90-100 DEG C for 1.5 hours, the temperature is cooled to 35 DEG C, and 200 parts by weight of water is added; the temperature is cooled to 20 DEG C, and centrifugation and washing are carried out in order to obtain a finished product.

Description

technical field [0001] The invention relates to a production method of chemical substances, in particular to a method for producing 2-(N-methylchloroacetamido)-5-chlorobenzophenone. Background technique [0002] 2-(N-Methylchloroacetamido)-5-chlorobenzophenone is used as a pharmaceutical intermediate, mainly used in the preparation of sedative drugs such as chlordiazepoxide, diazepam, and diazepam. The control of the above-mentioned drugs is relatively strict, so compared with the pharmaceutical intermediates of some anti-inflammatory drugs, their demand is smaller. Therefore, the production research and development of this kind of pharmaceutical intermediates is also less. In the prior art, the production process of 2-(N-methylchloroacetamido)-5-chlorobenzophenone is complicated, and in the existing method, 2-(N-methylchloroacetamido)-5- The production rate of chlorobenzophenone is not high, which wastes the production cost of the company. Contents of the invention [...

Claims

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Application Information

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IPC IPC(8): C07C231/02C07C233/88
CPCC07C231/02C07C221/00C07D261/20C07C233/88C07C225/22
Inventor 陈金勇
Owner 枣阳凤泽环化科技有限公司
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