Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity

Abstract

Peptide system comprising at least one peptide blocking the presynaptic release of glutamate, said peptide having sequence SEQ ID NO 5: GRKKRRQRRRPPIEQSIEQEEGLNRS; and / or sequence SEQ ID NO 8: GRKKRRQRRRPPMSEYNATQSDYRER for use in treating pathologies associated with glutamate excitotoxicity.

Description

technical field [0001] The present invention relates to the medical field. In more detail, the present invention relates to novel peptide systems capable of blocking NMDA-induced presynaptic release of glutamate. The peptide systems of the invention are useful in the treatment of conditions associated with glutamate excitotoxicity. Background technique [0002] One of the most abundant amino acids in the brain is L-glutamate. Its most important function at the neuronal level is the control of excitatory neurotransmission, which has been described since the 1950s, and its physiological antagonist is gamma-aminobutyric acid (GABA). [0003] L-glutamate is considered a major mediator of excitatory signaling and rapid synaptic transmission in the central nervous system. L-glutamate plays an important role in the development of the central nervous system (CNS), in the formation and elimination of synapses, and in cell migration, differentiation and death. In addition, L-gluta...

AI Technical Summary

Problems solved by technology

Although JNK is commonly associated with postsynaptic NMDA receptors, its presynaptic role remains largely undiscovered

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