Application of serum exosomal miRNA markers in the early diagnosis of endemic arsenicosis

An early diagnosis and marker technology, applied in the fields of genetic engineering and clinical medicine, can solve the problems that the application of early diagnosis and monitoring of square arsenic poisoning has not received corresponding attention, and achieve easy screening and accurate quantitative analysis, and improve Sensitivity and specificity, easily detectable effects
CN106435004BInactive Publication Date: 2019-01-22NANJING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING MEDICAL UNIV
Publication Date
2019-01-22
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the field of gene engineering and clinical medicine and particularly relates to an endemic arsenism early diagnosis associated serum exosome miRNAs marker and application thereof. The marker is a combination of has-miR-155 and has-miR-191. The marker and a primer thereof can be used for preparation of a kit for early diagnosis of endemic arsenism.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering and clinical medicine, and specifically relates to serum exosome microRNAs (miRNAs) markers and applications thereof related to the early occurrence of endemic arsenicosis in humans. Background technique

[0002] Endemic arsenicosis, referred to as ground arsenic disease, is a biogeochemical disease, which is caused by the loss of skin pigmentation caused by long-term intake of excessive inorganic arsenic through drinking water, air or food by residents living in a specific geographical environment. Or / and excessive sedation, palmoplantar keratosis and cancerous systemic chronic poisoning. Arsenicosis is an endemic disease that seriously endangers human health. In addition to causing skin changes, inorganic arsenic is a human carcinogen identified by the International Center for Cancer Research, which can cause skin cancer, lung cancer, and high incidence of other visceral cancers. I...

Claims

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