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Method and apparatus for decoding multiplexed information in a chromatographic system

A technology of multiplexing and scheme, applied in the field of encoding and decoding multiplexed chromatography-mass spectrometry information, which can solve problems such as accelerated ions and reduced sensitivity

Active Publication Date: 2017-02-22
LECO CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long flight times limit how often ions can be accelerated, resulting in reduced sensitivity

Method used

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  • Method and apparatus for decoding multiplexed information in a chromatographic system
  • Method and apparatus for decoding multiplexed information in a chromatographic system
  • Method and apparatus for decoding multiplexed information in a chromatographic system

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Embodiment Construction

[0023] Now, refer to figure 2 , discloses an example mass spectrometer 10 configured to multiplex or encode ion packets and demultiplex or decode the resulting ion impacts. As illustrated, mass spectrometer 10 is a time-of-flight mass spectrometer. Note, however, that this disclosure relates to any suitable mass spectrometer. In some implementations, mass spectrometer 10 includes ion source 12 , pulse generator 14 , analyzer 16 , detector 18 , data processor 20 , and display device 21 . Note that mass spectrometer 10 may include figure 2 Additional components not pictured.

[0024] In operation, a sample 22 (eg, an analyte) is inserted into ion source 12 . Sample 22 may be a solid, liquid or gas. Ion source 12 forms charged particles (ie, ions) from sample 22 . Ion source 12 may be any suitable ion source 12 . For example, ion source 12 may be an electronic ion source, a chemical ion source, a radioactive ion source, an ion attachment ion source, a gas discharge ion s...

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Abstract

Implementations of methods and apparatuses are disclosed for decoding multiplexed information in a chromatographic system. Implementations may include the method of pulsing ions from an ion source through an analyzer according to a predetermined multiplexing scheme, each pulse including one or more ions corresponding to a sample, detecting a plurality of ion strikes at a detector, determining a data point for each ion strike, wherein each data point includes an intensity of a detected ion strike and a time of the detected ion strike, maintaining a multiplexed spectrum of the data points, the multiplexed spectrum including the data points, and demultiplexing the time shifted spectrum using the data points of the multiplexed spectrum.

Description

technical field [0001] The present disclosure relates to methods and apparatus for encoding and decoding multiplexed chromatography-mass spectrometry information. Background technique [0002] In a time-of-flight (TOF) mass spectrometer (MS), ions are accelerated with a substantially constant energy. It is understood that lighter ions will travel faster than heavier ions. The time it takes for ions to travel a fixed distance is measured. Therefore, this time of flight can then be used to calculate the mass of the ion. [0003] Ions of similar mass have substantially similar (short) flight times if the distance the ions travel is short. In some cases, these approximate times can result in ions of approximate mass not being distinguishable from each other, resulting in low resolution results. [0004] In order to increase the resolution resulting from this phenomenon, it is known to increase the distance (and thus time-of-flight) that ions have to travel. In this implemen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/40
CPCH01J49/0027H01J49/40H01J49/10
Inventor P·M·威利斯J·伽洛斯金斯基E·豪克
Owner LECO CORPORATION