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Tea polyphenol composition for controlling atherosclerosis

A technology for atherosclerosis and tea polyphenols, applied in drug combinations, medical preparations containing active ingredients, cardiovascular system diseases, etc., can solve problems such as poor quality control of green tea extracts, and achieve slowing down of aortic atherosclerosis Plaque formation, good effect

Active Publication Date: 2017-03-22
GUANGDONG GENERAL HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although green tea extract contains a variety of tea polyphenol monomers, the quality of green tea extract is not well controlled

Method used

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  • Tea polyphenol composition for controlling atherosclerosis
  • Tea polyphenol composition for controlling atherosclerosis
  • Tea polyphenol composition for controlling atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Effect experiment of the tea polyphenol composition of the present invention

[0029] Apoe- / - knockout mice are widely used animal models for studying atherosclerosis in the world. The Apoe- / - gene knockout mouse model can show abnormal hyperlipidemia, and fat deposition can occur in the arterial endothelium at the age of 3 months. As the mouse age increases, a large number of atherosclerosis-like In the early stage of injury, lipomatous fibroma, foam cells and lipid globules will appear in the brain of mice at the age of 17 months.

[0030] In this example, in order to improve the quality control of tea polyphenol extracts in drug efficacy research, the inventors used a combination of 8 kinds of tea polyphenol monomers to simulate green tea polyphenols according to the ratio of various components of green tea polyphenol extracts. Phenol extraction, wherein the inventors appropriately increased the proportion of active ingredients in order to improve the ...

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PUM

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Abstract

The invention provides a tea polyphenol composition for controlling atherosclerosis. The tea polyphenol composition comprises the following components: epigallocatechin gallate, epigallocatechin, epicatechin, epicatechin gallate, proanthocyanidins, cyaniding-3-glucoside, theaflavin and theaflavin-3-gallate. The tea polyphenol composition comprises eight kinds of tea polyphenol monomer substances, the quality is controllable, the tea polyphenol composition has good effects in the aspects of atherosclerotic prevention and treatment, so that body weight and blood sugar indexes of animal models with atherosclerosis tend to be normal, and generation of aorta atheromatous plaque of animal models with atherosclerotic is obviously alleviated.

Description

technical field [0001] The invention relates to a composition, including a tea polyphenol composition for preventing and treating atherosclerosis. Background technique [0002] In recent years, with the development of society and economy, the change of eating habits and environment, the aggravation of the pace of life and the acceleration of population aging process, coronary heart disease (CHD, referred to as coronary heart disease, also known as The incidence of ischemic heart disease (CHD) is showing a sharp increase trend, and coronary heart disease ranks first in the cause of death in the United States and many developed countries. With the increase of life pressure, the onset of coronary heart disease tends to be younger in recent years. It has been reported that patients with acute myocardial infarction, including teenagers, have become the main cause of sudden death and the number one killer that endangers human health. In my country, with economic and social develo...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10A61K31/353
Inventor 钟诗龙唐斓陈纪言蔡丽云刘叔文
Owner GUANGDONG GENERAL HOSPITAL
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