Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Synthesis method for medicinal raw material 2-chloro-4-ethoxyl-6-methylpyrimidine

The technology of a methylpyrimidine and a synthetic method is applied in the field of synthesis of medical raw material 2-chloro-4-ethoxy-6-methylpyrimidine, which can solve problems such as synthetic methods of unreported compounds, and achieve a simple and efficient synthetic method. Operational safety and the effect of meeting the response requirements

Inactive Publication Date: 2017-03-22
WUXI QIANHAO BIOPHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The synthesis method of 2-chloro-4-ethoxy-6-methylpyrimidine is the starting material for the synthesis of many drugs, especially the important intermediates of many methylpyrimidine compounds. There is no report on the synthesis method of this compound in China at present.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The synthetic method of medical raw material 2-chloro-4-ethoxy-6-methylpyrimidine of the present invention is specifically as follows:

[0009] Using methyl pyrimidine as raw material, under the action of solvent n-butanol and 1.5 atmospheric pressure, under the catalysis of vanadium pentoxide, at a temperature of 100°C-145°C, 2-chloro- Synthetic method of 4-ethoxy-6-methylpyrimidine. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a synthesis method for a medicinal raw material 2-chloro-4-ethoxyl-6-methylpyrimidine. According to the synthesis method, methylpyrimidine serves as a raw material, and under the effect of solvent n-butyl alcohol and 1.5 atmospheric pressure, the 2-chloro-4-ethoxyl-6-methylpyrimidine is generated sequentially through ethylation, an oxidation reaction and a chlorine replacement reaction at 100-145 DEG C under catalysis of vanadium pentoxide. The synthesis method for the medicinal raw material 2-chloro-4-ethoxyl-6-methylpyrimidine is simple, efficient, safe to operate, quite practical in concrete production and capable of meeting common reaction requirements.

Description

technical field [0001] The invention relates to a synthesis method of medical raw material 2-chloro-4-ethoxy-6-methylpyrimidine. Background technique [0002] The synthesis method of 2-chloro-4-ethoxy-6-methylpyrimidine is the starting material for the synthesis of many drugs, especially the important intermediates of many methylpyrimidine compounds. There is no report on the synthesis method of this compound in China at present. Contents of the invention [0003] The object of the present invention is to overcome the above-mentioned shortcomings, and provide a simple, efficient and safe synthetic method for medical raw material 2-chloro-4-ethoxy-6-methylpyrimidine. [0004] The purpose of the present invention is achieved like this: [0005] A kind of synthetic method of medical raw material 2-chloro-4-ethoxyl-6-methylpyrimidine, using methylpyrimidine as raw material, under the action of solvent n-butanol and 1.5 atmospheric pressure, under the catalysis of vanadium pen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/34
CPCC07D239/34
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com