Synthesis method for medical body 3-aminopyrimidin-2-nitrile
The technology of an aminopyrimidine and a synthetic method is applied in the field of synthesis of medical body 3-aminopyrimidine-2-carbonitrile, can solve problems such as no reported synthetic method, and achieve the effects of simple synthetic method and safe operation
Inactive Publication Date: 2017-03-22
WUXI QIANHAO BIOPHARMA
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Problems solved by technology
[0002] The synthesis method of 3-aminopyrimidine-2-carbonitrile is the starting material for the synthesis of many drugs, especially the important intermediate of many pyrimidine nitriles. There is no report on the synthesis method of this compound in China at present.
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Experimental program
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Embodiment Construction
[0008] The synthetic method of medical body 3-aminopyrimidine-2-carbonitrile of the present invention is specifically as follows:
[0009] Using pyrimidine-2-carbonitrile as raw material, under the action of solvent acetone, under the pressure of one atmosphere, the synthetic method of generating 3-aminopyrimidine-2-carbonitrile through amination at a temperature of 105°C-160°C. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.
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The invention relates to a synthesis method for a medical body, i.e., 3-aminopyrimidin-2-nitrile. According to the synthesis method, the 3-aminopyrimidin-2-nitrile is produced from pyrimidin-2-nitrile, which serves as a raw material, through carrying out amination in the presence of a solvent, i.e., acetone at the temperature of 105 DEG C to 160 DEG C and the pressure intensity of one atmosphere. The synthesis method for the medical body, i.e., 3-aminopyrimidin-2-nitrile, disclosed by the invention, is simple and efficient and is safe in operation, so that the synthesis method is very practical in specific production.
Description
technical field [0001] The invention relates to a method for synthesizing medical substance 3-aminopyrimidine-2-carbonitrile. Background technique [0002] The synthesis method of 3-aminopyrimidine-2-carbonitrile is the starting material for the synthesis of many medicines, especially the important intermediate of many pyrimidine nitriles. At present, there is no report on the synthesis method of this compound in China. Contents of the invention [0003] The purpose of the present invention is to overcome the above-mentioned disadvantages, and provide a simple, efficient and safe synthetic method of medical substance 3-aminopyrimidine-2-carbonitrile. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing medical substance 3-aminopyrimidine-2-carbonitrile, using pyrimidine-2-carbonitrile as raw material, under the action of solvent acetone, under the pressure of one atmosphere, through amination at a temperature of 105°C-160...
Claims
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IPC IPC(8): C07D239/42
CPCC07D239/42
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA