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A dental implant with a bioactive surface containing rgd
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A dental implant, bioactive technology, applied in prosthesis, dentistry, dental implant and other directions, can solve the problems of implant loosening and falling off, peripheral bone tissue defect and loss, etc., and achieves broad application prospects and efficient sterilization effect.
Inactive Publication Date: 2019-06-11
DALIAN SANSHENG SCI & TECH DEV
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Problems solved by technology
Peri-implantitis can lead to the defect and loss of bone tissue around the implant, if not treated in time, it can lead to loosening and falling off of the implant
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Embodiment 1
[0039] (1) Clean the dental implant with titanium dioxide layer on the surface with deionized water, ethanol and acetone in sequence, dry it with nitrogen, put it in a vacuum drying oven, dry it at 60°C for 24 hours, and store it for later use ;
[0040] (2) Dissolving chitosan in 0.3% acetic acid solution to prepare a 0.5 mg / ml chitosan solution, the deacetylation degree of the chitosan is 50%, and the Mw is 1000 kDa.
[0041] (3) mixing the solution obtained in step (2) with liquid paraffin, the volume ratio is 0.1, and adding Span 80 with a volume concentration of 0.5%, adding the dispersant magnesium stearate simultaneously, the mixture of Span 80 and magnesium stearate The mass ratio is 2:1, stirring at room temperature for more than 1 hour to form a uniform water-in-oil emulsion;
[0042] (4) Add 1ml of cross-linking agent vanillin of 5mg / ml to the water-in-oil emulsion obtained in step (3), and react for 4 hours under stirring at 40° C. to obtain chitosan particles;
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Embodiment 2
[0046] (1) Clean the dental implant with titanium dioxide layer on the surface with deionized water, ethanol and acetone in sequence, dry it with nitrogen, put it in a vacuum drying oven, dry it at 60°C for 24 hours, and store it for later use ;
[0047] (2) dissolving chitosan in 3% acetic acid solution to prepare a 5mg / ml chitosan solution, the deacetylation degree of the chitosan is 98%, and the Mw is 1500kDa.
[0048] (3) mixing the solution obtained in step (2) with liquid paraffin, the volume ratio is 0.4, and adding Span 80 with a volume concentration of 1%, adding the dispersant magnesium stearate simultaneously, the mixture of Span 80 and magnesium stearate The mass ratio is 4:1, and stirred at room temperature for more than 1 hour to form a uniform water-in-oil emulsion;
[0049] (4) Add 10 mg / ml cross-linking agent vanillin 1 ml to the water-in-oil emulsion obtained in step (3), and react for 6 hours under stirring at 60° C. to obtain chitosan particles;
[0050] ...
Embodiment 3
[0053] The surface of the implant was polished, cleaned, and dried; with 100 μm TiO 2 Sandblast the surface of the implant with particles; then place it in a mixed acid etchant composed of hydrofluoric acid and hydrochloric acid for surface etching treatment, take out the implant, ultrasonically clean it, and dry it; then place the implant at 60°C, 5mol / Incubate in L NaOH solution for 48 hours, and then ultrasonically wash with water for later use.
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Abstract
The invention discloses a dental implant with the bioactive surface containing RGD. Specifically, While a dental implant structure is improved, the outer surface is also improved, and the dental implant with various numbers of coatings is built. The coatings mainly relies on electrostatic attraction between positive ions and negative ions to form molecular coatings arrayed orderly on the solid surface of the implant, and chitosan RGD and an AMP compound are biological materials which have good biodegradability and biocompatibility. Due to the fact that a chondroitin sulfate layer-antimicrobial peptide layer composite layer structure exists in the surface, the dental implant with the bioactive surface containing the RGD has lasting and efficient sterilizing and infection resistant abilities, and antibiosis and antiapopthosis activity can support adherency, survival, growing and differentiation of various cells (such as osteoblasts and cartilage cells), so that the dental implant with the bioactive surface containing the RGD has wide application prospects.
Description
technical field [0001] The invention belongs to the technical field of dental implants, in particular to a dental implant with a bioactive surface containing RGD. Background technique [0002] With the continuous development of dental implant technology and wide recognition by patients, it is also the fastest-growing specialty in stomatology in recent years. It has continuously made breakthroughs and is providing professional help to more patients with dental diseases. However, another current situation that has to be admitted is that the existing interventional devices are prone to infection after being implanted in the body. The main infection mechanism is that the bacteria entering the body first adhere to the surface of the material, and due to the rich nutrient environment in the body, the bacteria reproduce and form a protective biofilm. The presence of biofilms makes infections from medical devices particularly difficult to treat. [0003] Roos. Jansaker et al. foll...
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