NBD-organic amine fluorescence probe, and preparation method and application thereof

A technology of fluorescent probes and organic amines, which is applied in the field of NBD-organic amine fluorescent probes and its preparation, which can solve the problems of inability to develop paper-based detection devices, color changes of colorimetric probes that cannot be seen by the naked eye in a short time, etc. question
CN106565694AActive Publication Date: 2017-04-19BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Publication Date
2017-04-19

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Abstract

The invention discloses an NBD-organic amine fluorescence probe, and a preparation method and an application thereof. The structure of the fluorescence probe is represented by formula (1); and in the formula (1), m is 0 or an integer in a range of 1 to 5, n is 0 or an integer in a range of 1 to 5, m and n cannot be 0 simultaneously, and R1 is CH2 or a group shown in the description. The fluorescence probe provided by the invention is a fluorescent / colorimetric double-channel probe, allows the chromogenic change to be directly observed by naked eyes, and realizes monitoring observation through using a paper-based detection device. The NBD-organic amine fluorescence probe can be used as an endogenous hydrogen sulfide probe to detect the existence of biological hydrogen sulfide.
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Description

technical field

[0001] The invention relates to the field of biological hydrogen sulfide detection, and more specifically, to an NBD-organic amine fluorescent probe and its preparation method and application. Background technique

[0002] Hydrogen sulfide is an important endogenous signaling molecule with various biological functions. In different organs and tissues, hydrogen sulfide is cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate thiotransferase (3-MPST) / In vivo enzymatic products of enzymatic reactions of three different pathways of cysteine ​​aminotransferase (CAT). In the central nervous system, the biological concentration of hydrogen sulfide is 50-160 μM. Sulfide levels in plasma plasma were 10-100 μM. Studies have shown that the level of hydrogen sulfide in the body is correlated with many diseases, such as Alzheimer's disease, Down syndrome, diabetes and liver cirrhosis. Although hydrogen sulfide has been considered to be as...

Claims

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