Application of vaccarin in preparation of medicines for resisting diabetic lipid metabolism disorder

A kind of flavonoid glycosides and anti-diabetic technology of wangbuliuxing, which is applied in the development of anti-diabetic glucolipid metabolism disorder traditional Chinese medicine and the application field of preparation of anti-diabetic glucolipid metabolism disorder drug, can solve the problems of accelerating the healing speed of open wounds, and achieve Expand options, improve blood sugar and blood lipid effects

Inactive Publication Date: 2017-05-17
JIANGNAN UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Buliuxing mainly contains erythrine, triterpenoid saponins, flavonoid glycosides, lipids, cyclic peptides, fatty acids, and monosaccharides. Past laboratory studies have found that blancia glycosides can promote angiogenesis and accelerate open wound healing. The healing speed...

Method used

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  • Application of vaccarin in preparation of medicines for resisting diabetic lipid metabolism disorder
  • Application of vaccarin in preparation of medicines for resisting diabetic lipid metabolism disorder
  • Application of vaccarin in preparation of medicines for resisting diabetic lipid metabolism disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 12

[0009] Example 1 Preparation of type 2 diabetes model mice

[0010] Diabetic model mouse production method: referring to authoritative journals at home and abroad, we used streptozotocin (STZ) combined with high-fat diet (HFD) to induce type 2 diabetes model, and 6-week-old C57BL / 6J mice were fasted for 4 hours and then once A small dose of STZ (120mg / kg) was injected intraperitoneally, and the normal control group was injected with vehicle as a control. After 3 weeks, the diabetic model group was given a high-fat diet (21.8kJ / g, fat content 60%) until the experiment was completed, and the control group was given a normal diet (14.7kJ / g, fat content 13%).

Embodiment 2

[0011] Example 2 Experimental Grouping and the Intervention of Buliuxing Flavonoid Glycosides

[0012] Six-week-old C57BL / 6J mice were randomly divided into three groups:

[0013] (1) Normal mice-physiological saline group: as the normal control group, they were given normal diet and drinking water all the time, and after 5 weeks, they were subcutaneously infused with normal saline for 4 weeks as the control group of Vaccarin;

[0014] (2) Diabetes-saline group was induced by Streptozotocin (STZ) combined with high-fat diet (HFD), and after 5 weeks, saline was injected intraperitoneally for 4 weeks as Vaccarin. contrast;

[0015] (3) Diabetes-Flavone Glycoside Low Dose Group (1mg / kg): Type 2 diabetes model was induced by Streptozotocin (STZ) combined with high-fat diet (HFD), and Vaccarin was administered intraperitoneally after 5 weeks Injection for 4 weeks.

[0016] (4) Diabetes-Flavone Glycoside Low Dose Group (10mg / kg): Type 2 diabetes model was induced by Streptozotoci...

Embodiment 3

[0017] Embodiment 3 fasting blood glucose is measured

[0018] To measure fasting blood glucose, the mice were fasted overnight, and blood was collected from the tail vein with a blood glucose meter for measurement the next day.

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Abstract

The invention discloses application of vaccarin in preparation of medicines for resisting a diabetic lipid metabolism disorder, belonging to the field of traditional Chinese medicine preparation. The vaccarin is applied to development of the medicines for resisting the diabetic lipid metabolism disorder to obtain a better method for treating diabetes. After mice with type 2 diabetes are subjected to intraperitoneal injection of the vaccarin, the fasting plasma glucose level is significantly reduced; the levels of serum triglyceride (TG), total cholesterol (TCH) and low-density lipoprotein cholesterol (LDL-C) of the mice with type 2 diabetes are improved; the diabetic lipid metabolism disorder can be effectively changed by the vaccarin; the vaccarin is a traditional Chinese medicine for treating the diabetes, and can be developed as a novel medicine, a healthcare product and a nutrition for treating the diabetes; and novel path and means are provided for treatment of the diabetic lipid metabolism disorder.

Description

technical field [0001] The invention relates to the development of anti-diabetic glucolipid metabolism disorder traditional Chinese medicine, and specifically designs the application of bulicia flavonoid glycoside in the preparation of anti-diabetic glucolipid metabolism disorder medicine, which belongs to the field of traditional Chinese medicine development. Background technique [0002] Diabetes is one of the common metabolic diseases and one of the non-communicable chronic diseases that affect human health. The pathological features of diabetes are mainly due to impaired islet function or decreased sensitivity of target cells to insulin, which causes the body's own glucose and lipid metabolism disorder. Clinically, diabetes is often divided into type 1 diabetes and type 2 diabetes according to the etiology. According to the 2014 International Diabetes Federation survey, there are about 387 million diabetic patients in the world, and it is estimated that the number of dia...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61P3/06A23L33/00
CPCA61K31/7048A23V2002/00A23V2200/328A23V2200/3262
Inventor 邱丽颖孙海建朱雪雪蔡维维周跃涛
Owner JIANGNAN UNIV
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