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Pharmaceutical composition for preventing and treating insomnia and preparation method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for preventing and treating insomnia and its preparation, and can solve problems such as weakening and strengthening

Inactive Publication Date: 2017-05-31
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for drugs with multiple components, as the dose increases, the enhancement range of the pharmacological effects of different components is not necessarily the same, and the combined pharmacological effects will be related to the ratio of the actual dose, the threshold dose, and the enhancement range of the drug effect. Within a certain range, their pharmacological effects may cancel each other out, or enhance or weaken the effect of one party

Method used

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  • Pharmaceutical composition for preventing and treating insomnia and preparation method thereof
  • Pharmaceutical composition for preventing and treating insomnia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the pharmaceutical composition for preventing and treating insomnia and preparation method thereof

[0035] The composition and parts by weight of the raw materials of the pharmaceutical composition for preventing and treating insomnia are: 485g of black fern, 455g of blue tang fruit, 6g of saikosaponin C6g, 385g of purple teak, and 347g of Ligusticum edulis;

[0036] Preparation:

[0037] (1) According to the ratio of raw materials, take black fern, blue ingot fruit, saikosaponin C, purple teak, and Ligusticum edulis, mix them evenly, use ethanol with a concentration of 28% by weight as a solvent, and extract by warm soaking at 35°C. 12 times, each extraction time is 10.5 hours, each solvent consumption is 18.5 times of the total weight of the crude drug, filtered to obtain medicinal residue A and extract A, the extract A reclaims ethanol, concentrates to a relative density of 1.17, and filters Afterwards, the medicinal solution passes through the HZ-801...

Embodiment 2

[0040] Embodiment 2: the pharmaceutical composition for preventing and treating insomnia and preparation method thereof

[0041] The composition and parts by weight of the raw materials of the pharmaceutical composition for preventing and treating insomnia are: 480g of black fern, 460g of sapikosaponin C5g, 390g of purple teak, and 346g of Ligusticum edulis;

[0042] Preparation:

[0043] (1) According to the ratio of raw materials, take black fern, blue ingot fruit, saikosaponin C, purple teak, and Ligusticum edulis, mix them evenly, use ethanol with a concentration of 28% by weight as a solvent, and extract by warm soaking at 35°C. 12 times, each extraction time is 10.5 hours, each solvent consumption is 18.5 times of the total weight of the crude drug, filtered to obtain medicinal residue A and extract A, the extract A reclaims ethanol, concentrates to a relative density of 1.17, and filters Afterwards, the medicinal solution passes through the HZ-801 macroporous adsorptio...

Embodiment 3

[0046] Embodiment 3: the pharmaceutical composition for preventing and treating insomnia and preparation method thereof

[0047] The composition and parts by weight of the crude drug of the pharmaceutical composition for preventing and treating insomnia are: 490g of black fern, 450g of blue tang fruit, 7g of saikosaponin C7g, 380g of purple teak, and 348g of Ligusticum edulis;

[0048] Preparation:

[0049] (1) According to the ratio of raw materials, take black fern, blue ingot fruit, saikosaponin C, purple teak, and Ligusticum edulis, mix them evenly, use ethanol with a concentration of 28% by weight as a solvent, and extract by warm soaking at 35°C. 12 times, each extraction time is 10.5 hours, each solvent consumption is 18.5 times of the total weight of the crude drug, filtered to obtain medicinal residue A and extract A, the extract A reclaims ethanol, concentrates to a relative density of 1.17, and filters Afterwards, the medicinal solution passes through the HZ-801 ma...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating insomnia and a preparation method thereof. The pharmaceutical composition is prepared from the following bulk pharmaceuticals of doryopteris concolor, lonicera caerulea, saikoside C, stem and leaves of tectona grandis and nothosmyrnium japonicum miq according to a certain proportion. The pharmaceutical composition can be prepared into various dosage forms according to the conventional preparation process, and has a remarkable curative effect of preventing and treating the insomnia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for preventing and treating insomnia and a preparation method thereof. Background technique [0002] During normal sleep, the secretion of human cytokines has a certain circadian rhythm. Studies have shown that cytokines IL-1, IL-6 and TNF increase during sleep at night and have a hypnotic effect, TNF and IL-1 jointly regulate physiological sleep; in addition, TNF-α mRNA, IL-1β mRNA and the corresponding receptors Physical energy is expressed in the brain, and its level shows a clear circadian rhythm; but there are also reports on the contrary, TNF-α and IL-1β are significantly increased when animals wake up, and this result may be caused by sleep deprivation. Drugs currently on the market for the treatment of insomnia mainly include: ① benzodiazepines; ② non-benzodiazepine receptor agonists, non-benzodiazepine drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P25/20A61K31/7048
CPCA61K36/85A61K31/7048A61K36/12A61K36/23A61K36/355A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 不公告发明人
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD