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Pharmaceutical composition for treating helicobacter pylori infection and application of pharmaceutical composition

A technology of Helicobacter pylori and a composition, which is applied in the field of pharmaceutical compositions for treating Helicobacter pylori infection, can solve the problems of decreased eradication rate, irregular treatment plan, poor grasp of eradication indications, etc., and achieves high eradication rate and effective rate. Effect

Active Publication Date: 2017-05-31
DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to factors such as the abuse of antibiotics, irregular treatment plans, and poor control of eradication indications, the problem of drug resistance of Helicobacter pylori is becoming more and more serious, and the eradication rate is also declining.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0049]Take 4.95kg of Nepeta chinensis and 3.3kg of Shuituanhua, extract by steam distillation, add 8.25kg of water, and obtain a total of about 21g of volatile extract, which is the volatile extract.

preparation example 2

[0051] Take 4.95kg of Nepeta chinensis and 3.3kg of Shuituanhua, and use supercritical carbon dioxide extraction method to extract, and obtain a total of about 23g of volatile extract, which is the volatile extract.

preparation example 3

[0053] 20 g of the volatile extract prepared by the method in Example 1 was added to 160 g of β-cyclodextrin to obtain an inclusion compound, and the content of the volatile extract in the inclusion compound was 11.2 wt%.

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Abstract

The invention discloses a pharmaceutical composition for treating helicobacter pylori infection and application of the pharmaceutical composition. The pharmaceutical composition is prepared from, by weight, 7.5-40 parts of proton pump inhibitor, 150-1000 parts of antibiotic, 220-300 parts of bismuth agent and 60-140 parts of volatile extracts, wherein the proton pump inhibitor is selected from one of omeprazole, lansoprazole, esomeprazole, pantoprazole and rabeprazole; the antibiotic is selected from one of amoxicillin, clarithromycin, levofloxacin, metronidazole, furazolidone, tetracycline and minocycline; the bismuth agent is selected from one of bismuth potassium citrate, colloidal bismuth subcitrate and colloidal bismuth pectin; the volatile extracts are volatile components extracted from chenopodium ambrosioides and twigs and leaves of Pilular Adina. By means of the pharmaceutical composition, the eradication rate of helicobacter pylori can be improved, the effective rate is increased, and the drug resistance rate and the rate of adverse reactions are reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating Helicobacter pylori infection, and also relates to the application of the pharmaceutical composition. Background technique [0002] Helicobacter pylori (H. pylori) is a helical, slightly anaerobic, Gram-negative bacillus that requires very harsh growth conditions. It is the only microbial species known to survive in the human stomach. In 1982, Australian scholars Marshall and Warren discovered H. pylori and clarified the role of H. pylori in gastritis and peptic ulcer disease. In 1994, the World Health Organization officially identified H. pylori as a class I (ie definite) carcinogen. The discovery of H. pylori has revolutionized the world's understanding of gastric diseases, treatment concepts and methods, making gastroduodenal diseases, especially peptic ulcer disease, no longer a long-term, incurable and frequent recurrence disease. disease and become curable with only short-course...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K36/74A61K36/185A61P1/04A61P31/04A61K31/4439A61K31/7048A61K31/5383A61K31/43A61K31/194
CPCA61K31/194A61K31/43A61K31/4439A61K31/5383A61K31/7048A61K36/185A61K36/74A61K45/06A61K2236/331A61K2236/37A61K2300/00
Inventor 江锋
Owner DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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