A magnetic resonance contrast agent based on magnetic dextran hydrogel microspheres and its preparation method
A technology of magnetic resonance contrast agent and dextran water, which is used in nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, pharmaceutical formulations, etc. Low, limited clinical diagnostic applications and other problems, to achieve the effect of significant enhancement, high transverse relaxation efficiency, good biocompatibility
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Embodiment 1
[0041] Embodiment 1: A preparation method of magnetic resonance contrast agent based on magnetic dextran hydrogel microspheres, the specific steps are as follows:
[0042] (1) Water-soluble Fe 3 o 4 Preparation of nanoparticles: Weigh 0.9g of dextran (the molecular weight of dextran is 40000g / mol) and place it in a two-neck flask, add 25mL of deoxygenated distilled water and stir until completely dissolved, weigh 0.093g of ferrous salt FeCl 2 4H 2 O and 0.192g ferric salt FeCl 3 ·6H 2 O, under the protection of argon, dissolve the iron salt in the aqueous dextran solution, and then add the ammonia water with a concentration of 25% dropwise under stirring until the pH of the solution reaches 11 to obtain a mixed solution of A, and the mixed solution of A is heated to React at 80°C for 1 hour, cool down to room temperature naturally, place the resulting reaction solution in a regenerated cellulose dialysis bag (the molecular weight cut-off of the regenerated cellulose dialys...
Embodiment 2
[0046] Embodiment 2: A method for preparing a magnetic resonance contrast agent based on magnetic dextran hydrogel microspheres, the specific steps are as follows:
[0047] Preparation of magnetic dextran hydrogel microspheres: Weigh 0.2 g of the aldehylated dextran solid obtained in step (2) of Example 1 and dissolve it in 1.0 mL of deionized water to obtain an aqueous solution of aldylated dextran (aldehylated The concentration of aldylated dextran in the dextran aqueous solution is 200 mg / mL), and then add 0.1 mL of Fe obtained in step (1) 3 o 4 Nanoparticle aqueous solution, stirred evenly to obtain C mixed solution (mass ratio of Fe element to formylated dextran in C mixed solution is about 0.2:100); mix sorbitan oleate (Span80) and sorbitan A compound emulsifier of monooleate polyoxyethylene ether (Tween80) (the mass ratio of sorbitan oleate to sorbitan monooleate polyoxyethylene ether is 10:1.5) dissolved in cyclohexane cyclohexane solution in cyclohexane (the solid-t...
Embodiment 3
[0048] Embodiment 3: A method for preparing a magnetic resonance contrast agent based on magnetic dextran hydrogel microspheres, the specific steps are as follows:
[0049] (1) Preparation of aldylated dextran: At room temperature, weigh 5.0 g of dextran (the molecular weight of dextran is 40,000 g / mol) and dissolve it in 50 mL of deionized water to obtain an aqueous solution of dextran (aqueous solution of dextran The solid-to-liquid ratio of dextran to deionized water (g:mL is 10:100); put the dextran aqueous solution in an ice water bath, dissolve sodium periodate in the dextran aqueous solution to obtain a mixed solution of B, where B The sugar unit of dextran and the IO of sodium periodate in the mixed solution 4 - The molar ratio is 1:1; at room temperature, under the condition of avoiding light and magnetic stirring, the mixed solution of B is reacted for 4 hours; the obtained reaction solution is placed in a regenerated cellulose dialysis bag (the molecular weight cut...
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