Method and system for detecting abnormity of liquid flow in hydrodynamic sequential system channel

Abstract

The invention discloses a method and a system for detecting abnormity of a liquid flow in a hydrodynamic sequential system channel. The method comprises steps as follows: flow characteristic value distribution of flowing cells in a preset section of the hydrodynamic sequential system channel within a preset period is counted; a characterization parameter is calculated on the basis of the flow characteristic value distribution, the characterization parameter characterizes the degree of deviation of flow characteristic values of flowing cells from a normal range, and the normal range refers to a flow characteristic value range of the cells flowing through the preset section when the liquid flow in the hydrodynamic sequential system channel is normal; whether the characterization parameter exceeds the preset range or not is judged, if yes, the liquid flow in the hydrodynamic sequential system channel is judged to be abnormal. The method and the system for detecting abnormity of the liquid flow in the hydrodynamic sequential system channel detect abnormity of the liquid flow according to statistical results of the flow characteristic values of flowing cells in the channel and can detect liquid flow abnormity caused by either micropore blockage or existence of impurities, bubbles and the like in the liquid flow, and thus the flow abnormity of the liquid flow in the hydrodynamic sequential system channel is effectively detected.

Description

technical field [0001] The invention relates to the technical field of cell analysis instruments, in particular to a method and system for detecting abnormal liquid flow in a channel of a sheath flow system. Background technique [0002] Blood cell analyzer is a commonly used clinical laboratory instrument for classifying and counting various constituent cells in blood, and plays an important role in clinical, teaching, scientific research and other work. [0003] Among them, the double sheath flow system (Double Hydrodynamic Sequential System, DHSS) is a type of analysis technology for classifying white blood cells in blood, usually dividing white blood cells into lymphocytes, monocytes, neutrophils, eosinophils and basophils granulocytes. The basic principle of the double sheath flow system is: refer to figure 1 As shown, there are two detection devices in the flow channel 3, wherein the sheath flow microwell 1 is used to measure the cell volume based on the electrical i...

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Problems solved by technology

However, when the micropores are blocked, or there are impurities or air bubbles in the liquid flow, the liquid flow in the channel will be unstable, so that the cells cannot pass through the micropore 1 and the light window 2 in sequence, which will lead to abnormal detection by the analyzer. State, for example, the impedance signal and light absorption signal generated by the same cell match incorrectly or generate interference signals, resulting in abnormalities in the obtained two-d

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