A kind of preparation method of Xinxinshu capsule

A technology of Xinxinshu capsules and parts by mass, applied in the field of preparation of Chinese patent medicines, can solve the problems of rational utilization of unfavorable resources, increase the difficulty of granulation process, unfavorable absorption of active ingredients, etc., and achieve the effect of improving curative effect.

Active Publication Date: 2020-02-14
SHAANXI DONGKE PHARMA
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Problems solved by technology

[0005] Part of the Radix Paeoniae Rubra in the original process is crushed into medicine, which is not conducive to the absorption of active ingredients, and the requirements for the particle size and uniformity of the extract powder (including the original medicinal material powder) are relatively high during the granulation process, and direct crushing will easily cause uneven distribution and damage to the extract. The specific gravity difference between the powder and the raw material powder will increase the difficulty of the granulation process
[0006] The research found that the original extraction process cannot guarantee the full extraction of active ingredients, and the transfer rate is low, which leads to an increase in the amount of medicinal materials and is not conducive to the rational use of resources. Research, explore a new preparation method according to the properties of the active ingredients of each medicinal material

Method used

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  • A kind of preparation method of Xinxinshu capsule
  • A kind of preparation method of Xinxinshu capsule
  • A kind of preparation method of Xinxinshu capsule

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Embodiment Construction

[0025] By reviewing the literature, the analysis and research on the medicinal ingredients of the four medicinal materials of Astragalus, Dihuang, Schisandra and Guizhi found that decoction cannot completely extract the main active ingredients in the medicinal materials, especially the fat-soluble ingredients, and protein, Ineffective components such as starch and chlorophyll are also extracted. The present invention selects the alcohol extraction method to extract the four herbs, that is, extracts the components of the medicinal materials with ethanol at a suitable concentration. . In this way, active ingredients such as alkaloids and their salts, glycosides, volatile oils, and organic acids can be extracted, and the leaching of starch, protein, mucus, etc. can be avoided at the same time; , part of the Radix Paeoniae Rubra in the original process was changed into ethanol reflux extraction; the main pharmacological active ingredients in Danshen include both fat-soluble compon...

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Abstract

The invention discloses a preparation method of Xinxinshu capsules. The method comprises the following steps: sorting and cleaning radix astragali seu hedysari, radix rehmanniae, fructus schisandrae chinensis, radix et rhizoma salviae miltiorrhizae, red paeony root, cassia twig and total saponins of panax ginseng, and extracting; drying extracted thick paste in vacuum; crushing the thick paste into fine powder; adding a proper amount of fine powder of stem and leaf total saponins of panax ginseng and starch; granulating in by one step and sieving; filling loading into capsules to prepare 1000 capsules; packaging with an aluminum foil to prepare the Xinxinshu capsules. The determination of content of main effective components and the pharmacological effect evaluation prove that the Xinxinshu capsules prepared by the invention can improve the content of the effective components, the dosage of the product is reduced and the curative effect of the product is improved.

Description

technical field [0001] The invention belongs to the preparation of Chinese patent medicines, and relates to a preparation process of Chinese patent medicines, in particular to a method for extracting and preparing the existing drug Xinxinshu Capsules (Z20025709) with an organic solvent. Background technique [0002] With the development of society and economy, the change of people's life style and life pattern, the prevalence rate of angina pectoris and coronary heart disease is increasing year by year. Mechanistically, angina pectoris of coronary heart disease is caused by insufficient coronary blood supply and temporary severe myocardial ischemia and hypoxia. resulting clinical syndrome. Traditional Chinese medicine believes that "wind is the root of all diseases", "the lungs face all channels", and external evils invade the human body, causing a series of diseases. Coronary heart disease angina pectoris is a syndrome of deficiency in origin and excess in superficiality. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/48A61P9/10A61P9/00
CPCA61K9/4866A61K36/258A61K36/481A61K36/537A61K36/54A61K36/57A61K36/65A61K36/71A61K36/79A61K36/804A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 杜杉夏传涛
Owner SHAANXI DONGKE PHARMA
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