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Traditional Chinese medicine composition for treating chronic cardiac failure as well as preparation method and application thereof

A technology for chronic heart failure and composition, which is applied in the field of traditional Chinese medicine compositions for the treatment of chronic heart failure, can solve the problems of obvious side effects, lack of objective basis for the selection of drugs and doses, and unstandardized heart failure syndrome differentiation and classification, and achieves low side effects. Effect

Inactive Publication Date: 2017-06-13
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although western medicine has achieved certain effects in the treatment of CHF, its clinical application is greatly limited due to obvious side effects.
Traditional Chinese medicine has made great progress in treating chronic heart failure, improving patients' clinical symptoms, and improving the quality of life. However, there are still some problems that restrict the further development of traditional Chinese medicine in treating heart failure. For example, the syndrome differentiation of heart failure is not standardized enough, Physicians use specific symptoms as the basis for syndrome differentiation, and there is no objective basis for the selection of drugs and dosages

Method used

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  • Traditional Chinese medicine composition for treating chronic cardiac failure as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating chronic cardiac failure as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: powder

[0022] Weigh the following raw materials: Poria 15g, Sanleng 10g, Astragalus 5g, Tinglizi 5g, Ophiopogon japonicus 10g, Zezhu 10g, put them in a closed container and boil twice, add 8 times the amount of water for the first time, and keep warm at 90 degrees Celsius after boiling After 30 minutes, the decoction liquid was obtained; for the second time, 6 times the amount of water was added, and after boiling, the temperature was kept at 90 degrees Celsius for 20 minutes to obtain the second decoction liquid; the second decoction liquid was combined, filtered, and the filtrates were combined. Concentrate under reduced pressure, dry under reduced pressure to obtain dry extract, and grind into fine powder (over 80 mesh). with CO 60 Sterilization (irradiation dose 8k). Taking method: 1.56g each time, 2 times a day, 7 days a week, 2 weeks as a course of treatment.

Embodiment 2

[0023] Embodiment 2: tablet

[0024] Weigh the following raw materials: Poria 15g, Sanleng 10g, Astragalus 5g, Tinglizi 5g, Ophiopogon japonicus 10g, Zezhu 10g, put them in a closed container and boil twice, add 8 times the amount of water for the first time, and keep warm at 90 degrees Celsius after boiling After 30 minutes, the decoction liquid was obtained; for the second time, 6 times the amount of water was added, and after boiling, the temperature was kept at 90 degrees Celsius for 20 minutes to obtain the second decoction liquid; the second decoction liquid was combined, filtered, and the filtrates were combined. Concentrate under reduced pressure, dry under reduced pressure to obtain a dry extract, and then add appropriate amount of auxiliary materials to obtain tablets. Each tablet contains 312.5 mg of the traditional Chinese medicine composition. Dosage: 5 tablets each time, 2 times a day, 7 days a week, 2 weeks as a course of treatment.

Embodiment 3

[0025] Embodiment 3: Granules

[0026] Weigh the following raw materials: Poria 7.5g, Sanleng 5g, Astragalus 60g, Tinglizi 60g, Ophiopogon japonicus 5g, Curcuma zedoary 5g, put them in a closed container and boil twice, add 8 times the amount of water for the first time, and boil at 90 degrees Celsius Keep it warm for 30 minutes to obtain a decoction; add 6 times the amount of water for the second time, and heat it at 90 degrees Celsius for 20 minutes after boiling to obtain a second decoction; combine the second decoction, filter, and combine the filtrates. Concentrate under reduced pressure, dry under reduced pressure to obtain dry extract, and then add appropriate amount of dextrin as auxiliary material to obtain granules, each gram containing 3.125g of crude drug. Each bag weighs 10 grams (containing crude drug 31.25g). Taking method: 10g each time, 2 times a day, 7 days a week, 2 weeks as a course of treatment.

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Abstract

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating chronic cardiac failure as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 7.5-75 parts of poria cocos, 5-50 parts of sparganium stoloniferum, 5-6 parts of astragalus membranaceus, 5-60 parts of semen lepidii, 5-50 parts of radix ophiopogonis and 5-50 parts of curcuma zedoary. The astragalus membranaceus in the embodiment of the invention has effects of tonifying qi and promoting urination, the semen lepidii has effects of purging pathogenic lung fire and cleaning body fluid and is used as a monarch drug, the poria cocos has effects of invigorating spleen, supplementing qi and promoting urination, the radix ophiopogonis has effects of nourishing yin, retaining yin and promoting urination and is used as a ministerial drug, the sparganium stoloniferum and the curcuma zedoary have effects of promoting blood circulation to remove blood stasis and are used as adjuvant drugs, so that the traditional Chinese medicine composition has the advantages of tonifying qi and promoting urination, purging pathogenic lung fire and cleaning body fluid, invigorating spleen and promoting urination, nourishing yin, retaining yin and promoting urination as well as activating blood and removing stasis, in addition the traditional Chinese medicine composition can treat both symptoms and root causes, is simple and convenient to take as a decoction, is capable of removing blood stasis without damaging yin and is low in side effect, and thus the purpose of effectively treating chronic cardiac failure can be achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating chronic heart failure, a preparation method and application. Background technique [0002] Chronic heart failure (CHF), also known as chronic congestive heart failure, refers to the condition that the venous return is normal, the cardiac output is absolutely or relatively lower than the body's metabolic needs and the ventricular filling pressure is increased due to different etiologies. High, CHF is a slow process that is the final developmental outcome of most cardiovascular diseases. In recent years, the incidence and prevalence of CHF have been increasing. At present, the prevalence of CHF in the world is about 1.5% to 2.0%, and it can reach 6% to 10% for those over 65 years old. The prevalence of CHF in my country is 0.9%. But still growing year by year. Deaths from CHF have increased six-fold over the past 4...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/04
CPCA61K36/076A61K36/31A61K36/481A61K36/8968A61K36/902A61K36/9066A61K2236/331A61K2236/39A61K2300/00
Inventor 刘永明蒋梅先鲁成宋磊
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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