Photosensitizer formula for photodynamically treating periodontitis, as well as preparation method and application thereof

Abstract

The invention discloses a photosensitizer formula for photodynamically treating periodontitis and an application thereof. A hydrogel preparation for treating periodontitis takes toluidine blue as a photoactive substance and carbopol as a gel. A formula for optimizing the gel preparation comprises the following components by mass concentration: 0.05%-3% of carbopol, 0.001%-1% of toluidine blue, 0.01%-0.4% of sodium hydroxide or 0.07%-2% of triethanolamine and the balance of water. A method for photodynamically treating periodontitis, provided by the invention, can be used for replacing an antibiotic therapy, so that the problem of antibiotics abuse can be prevented; when the preparation is used for treating the oral diseases caused by infections, such as, periodontitis, the antibacterial rate of once irradiation treatment can reach up to 99.99%; serious patients can be repeatedly treated at intervals; and the photosensitizer formula is free from toxic or side effect to normal organ tissues and has wide market prospects and high application values.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to microbiology, in particular to a photosensitive gel preparation product for photodynamic treatment of periodontitis, its preparation method and application. Background technique [0002] Periodontitis is one of the three major diseases of the oral cavity announced by the World Health Organization (WHO). Bone and cementum) chronic infectious disease of inflammation and destruction. The third oral epidemiological survey in my country shows that the prevalence of periodontitis in the population over 35 years old is as high as 80%-90%. It is the most widespread chronic infectious disease in the population and seriously affects oral health, causing bleeding and swelling of the gums. , Alveolar bone resorption forms periodontal pockets and other lesions, and is also the main cause of adult tooth looseness and loss. In addition, a large number of research results in the past ten years...

AI Technical Summary

Problems solved by technology

The complex tooth structure limits the effect of mechanical debridement, such as subgingival scaling and root planing. Although most of the calculus and plaque on the root surface can be removed, it cannot effectively remove the epithelial lining of the periodontal pocket and complex pockets. Therefore, various basic auxiliary or further surgical treatments are required, such as systemic or topical antibiotics, and mechanical debridement is relatively complicated, and it is not easy for doctors in primary hospitals to master it.

Although chemical sterilization pulp debridement using NaOCl, chlorhexidine digluconate, etc. as irrigation agents has a strong bactericidal effect, it still cannot completely remove all bacteria due to the short residence time of the drugs in the pulp

However, there are many problems in the current use of antibiotic treatment. If large doses are used, long-term systemic administration will lead to flora imbalance; when local administration is used, it is difficult for the medicine to stay in the affected area for a long time due to the washing of saliva, making its therapeutic effect unsatisfactory.

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