Sphingosine-1-phosphate receptor modulators for the treatment of cardiopulmonary disease
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A disease, C1-C4 technology, applied in the field of sphingosine-1-phosphate receptor modulators for the treatment of cardiopulmonary diseases
Active Publication Date: 2020-12-04
THE SCRIPPS RES INST
View PDF11 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Taken together, the available evidence strongly suggests that, with the systemic S1PR 3 Downregulation of S1PR proposed by antagonists 3 DC signaling may open new therapeutic opportunities in sepsis syndrome
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment
[0271] Compounds that selectively alter the action of the sphingosine-1-phosphate receptor (S1P-R) and thus have the potential to treat cardiovascular and / or pulmonary diseases or disorders are presented. These diseases / conditions include, but are not limited to: cardiovascular disease, hypertension (including malignant hypertension), angina, myocardial infarction, arrhythmia, congestive heart failure, coronary heart disease, atherosclerosis, angina, dysrhythmia, myocardial (including hypertensive cardiomyopathy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary Embolism, pulmonary hypertension, mesothelioma, ventricular conduction abnormality, complete cardiac obstruction, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prophylaxis Keloid formation, liver c...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The present invention provides compounds effective as sphingosine-1-phosphate receptor modulators for the treatment of cardiopulmonary disorders such as hypertension (including malignant hypertension), angina, myocardial infarction, arrhythmia , congestive heart failure, coronary heart disease, atherosclerosis, angina, dysrhythmia, cardiomyopathy (including hypertensive cardiomyopathy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis , croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolism, pulmonary hypertension, mesothelioma, ventricular conduction abnormalities, complete cardiac obstruction, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary Fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 056,946, filed September 29, 2014, the disclosure of which is incorporated herein by reference in its entirety. [0003] Statement of Government Support [0004] This invention was made with US government support (National Institutes of Health Grant No. MH084512). Accordingly, the US Government may have certain rights in this invention. Background technique [0005] Antagonism of sphingosine-1-phosphate receptor (S1PR) subtype 3 has been proposed for therapeutic use in asthma, chronic obstructive pulmonary disease and other therapeutic uses based on receptor expression and pharmacological antagonism of gene deletion. Five high-affinity G-protein-coupled receptors for sphingomyelin 1-phosphate (S1P) were identified (1), and S1PR 1 The crystal structure of (2). This collection of receptors is medically important because the nonselective S1PR...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more