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Application of calycosin in preparing anti-rotavirus drug

A technology of mullein and rotavirus, applied in the field of medicine, can solve the problems such as the limited range of RV strain diversity prevention, the lack of specific drugs for preventing and treating RV infection, the high price of RV vaccine, etc., and the effect of good guiding value can be achieved.

Active Publication Date: 2017-08-15
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Rotavirus (RV) is the main pathogen that causes acute diarrhea in infants and young children. About 600,000 infants and young children die from RV infection every year. Currently, there is no specific drug for preventing and treating RV infection.
As for the RV vaccine, it is still in the research stage in China, and the RV vaccine marketed abroad is expensive, and the diversity of RV strains makes the scope of prevention limited.

Method used

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  • Application of calycosin in preparing anti-rotavirus drug
  • Application of calycosin in preparing anti-rotavirus drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Application of calycosin in the preparation of anti-rotavirus drugs.

[0016] The application of the actcocosin in the preparation of the anti-rotavirus drug reveals that the actcocosin can be used in the preparation of the anti-rotavirus drug, and the application can provide significant value for the development of safe and effective drugs for the prevention and treatment of rotavirus infection.

[0017] Moreover, the application of calycosin in the preparation of anti-rotavirus drugs in this example reveals that in the anti-rotavirus drugs, the molar concentration of calycocosin in the anti-rotavirus is 10umol / L-80umol / L, that is, reveals It shows that at a certain drug concentration, calycocoside can prevent and treat rotavirus infection well, and reveals that in anti-rotavirus drugs, the molar concentration of calycocoside that is toxic to cells is greater than 80umol / L, and then has a great impact on the utilization of calycocoside. Antirotavirus drugs provide a go...

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Abstract

The invention relates to the technical field of medicines and in particular relates to application of calycosin in preparing an anti-rotavirus drug. The application of calycosin in preparing the anti-rotavirus drug discloses that calycosin can be applied to preparing the anti-rotavirus drug. The application can provide extremely meaningful values for developing safe and effective drugs for preventing and treating rotavirus infection. Moreover, the application of calycosin in preparing the anti-rotavirus drug discloses that the anti-rotavirus molar concentration of calycosin is 10-80mu mol / L in the anti-rotavirus drug, that is, under a certain drug concentration, calycosin can better prevent and treat rotavirus infection, and discloses that in the anti-rotavirus drug, the molar concentration of calycosin generating cytotoxicity is greater than 80mu mol / L, so that a good guiding value is provided for utilizing calycosin to prepare the anti-rotavirus drug.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of calycosin in the preparation of anti-rotavirus drugs. Background technique [0002] Rotavirus (RV) is the main pathogen that causes acute diarrhea in infants and young children. About 600,000 infants and young children die from RV infection every year. Currently, there is no effective drug to prevent and treat RV infection. As for the RV vaccine, it is still in the research stage in China, and the RV vaccine listed abroad is expensive, and the diversity of RV strains makes the scope of prevention limited. Oral rehydration solution recommended by WHO is often used clinically to relieve symptoms. Therefore, it is very important to strengthen the research on the mechanism of rotavirus infection and develop safe and effective drugs to prevent and treat rotavirus infection. Contents of the invention [0003] The purpose of the present invention is to provide th...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P31/14
CPCA61K31/352
Inventor 赵文昌宋丽军
Owner GUANGDONG MEDICAL UNIV