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Ceftiofur hydrochloride injection for dairy cows and preparation method thereof

A technology for ceftiofur hydrochloride and injection, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, etc. problem, to achieve the effect of good dispersion stability, good needle penetration, and strong plasticity

Active Publication Date: 2020-02-14
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ceftiofur is easy to remain in the milk produced by cows, which makes the cows who have been injected with ceftiofur have a longer period of abandoning milk, which increases production costs and reduces production efficiency, and the penetrability of ceftiofur injection is poor. , prone to sedimentation, poor stability, not conducive to the injection of injection

Method used

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  • Ceftiofur hydrochloride injection for dairy cows and preparation method thereof
  • Ceftiofur hydrochloride injection for dairy cows and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] This embodiment provides a ceftiofur hydrochloride injection for cows, which consists of the following components in parts by mass: 10 parts of ceftiofur hydrochloride, 1 part of suspending agent, 0.1 part of citric acid, 0.02 part of hydrogenated castor oil, vitamin 0.5 parts of E, 60 parts of soybean oil and 5 parts of white oil; the suspending agent is aluminum stearate.

[0022] The present invention also provides the preparation method of described ceftiofur hydrochloride injection for cows, which comprises the following steps:

[0023] Mix the suspending agent and 50% of the soybean oil evenly, heat to 110-120°C, keep it warm for 1h, and cool to 70-80°C to obtain oil gel;

[0024] Mix the citric acid, the hydrogenated castor oil and the gelatin evenly, and cool to room temperature to prepare a mixed solution;

[0025] Mix the remaining amount of the soybean oil, the white oil, the vitamin E, the ceftiofur hydrochloride and the mixed solution evenly, and emulsify ...

Embodiment 2

[0027] This embodiment provides a ceftiofur hydrochloride injection for cows. The difference between this embodiment and Embodiment 1 is that the suspending agent is chitosan.

[0028] The present invention provides that the preparation method of the ceftiofur hydrochloride injection for cows is the same as that in Example 1.

Embodiment 3

[0030] This embodiment provides a ceftiofur hydrochloride injection for cows. The difference between this embodiment and Embodiment 1 is that the suspending agent is sodium carboxymethylcellulose.

[0031] The present invention provides that the preparation method of the ceftiofur hydrochloride injection for cows is the same as that in Example 1.

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PUM

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Abstract

The invention provides ceftiofur hydrochloride injection for dairy cattle, comprising, by weight, 5-10 parts of ceftiofur hydrochloride, 0.5-3 parts of a suspending agent, 0.05-5 parts of a flocculant, 0.01-2 parts of an emulsifier, 0.1-2 parts of an antioxidant, and 55-100 parts of a lipid solvent. The ceftiofur hydrochloride injection has good dispersion stability and good needle passage, milk withdrawal period of dairy cattle injected with the ceftiofur hydrochloride injection is short, and the ceftiofur hydrochloride injection has a promising application prospect. A preparation method of the ceftiofur hydrochloride injection for dairy cattle is also provided; the preparation method is simple to perform and applicable to industrial application.

Description

technical field [0001] The invention belongs to the field of animal medicines, and in particular relates to a ceftiofur hydrochloride injection for cows and a preparation method thereof. Background technique [0002] Ceftiofur, also known as Saidefu, is a third-generation cephalosporin antibiotic for animals. Ceftiofur has a spectrum bactericidal effect, strong antibacterial activity, and is effective against both Gram-positive and Gram-negative bacteria (including lactamase-producing bacteria). The sensitive bacteria are mainly Pasteurella multocida, Pasteurella hemolytica, Actinobacillus pleuropneumoniae, Salmonella, Escherichia coli, Streptococcus, Staphylococcus, Haemophilus, etc., and it is not easy to produce drug-resistant strains and cross-resistance It is mainly used to treat various infections caused by various animal sensitive bacteria, and is widely used in animal husbandry. [0003] At present, the approved preparations in my country include ceftiofur soluble ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/12A61K47/44A61K47/22A61K47/36A61K47/38A61K47/42A61K47/32A61K47/20A61K47/04A61K31/546A61P31/04
CPCA61K9/0019A61K9/107A61K31/546A61K47/02A61K47/12A61K47/20A61K47/22A61K47/32A61K47/36A61K47/38A61K47/42A61K47/44
Inventor 郭玉凡陈长青王颖王辉周衡李攀邓俊丁佳丽陈慧娟
Owner ZHENGZHOU BARY ANIMAL PHARMA