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Fe3O4 nano-particles with high dispersion stability in water phase, and preparation method thereof

A nanoparticle, highly dispersed technology, applied in the direction of nanotechnology, ferric oxide, iron oxide/iron hydroxide, etc., can solve the problems of physical and chemical properties change, blood vessel blockage, easy aggregation and sedimentation, etc., and achieve excellent affinity water effect

Inactive Publication Date: 2012-12-12
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the nanoscale and large surface energy of MNPs, they are easy to aggregate and settle in the biological environment, resulting in changes in their physical and chemical properties, and even easy to cause blood vessel blockage when applied in vivo.

Method used

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  • Fe3O4 nano-particles with high dispersion stability in water phase, and preparation method thereof
  • Fe3O4 nano-particles with high dispersion stability in water phase, and preparation method thereof
  • Fe3O4 nano-particles with high dispersion stability in water phase, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1) Weigh 36.5g (120mmol) sodium oleate and 6.5g (40mmol) FeCl 3 Dissolve in a mixture of 140mL n-hexane, 80mL absolute ethanol and 60mL deionized water. After the solid is completely dissolved, transfer the solution into a 500mL three-necked flask, turn on the cooling water, heat the oil bath to 70°C, and stir mechanically for 4 hours. Then stop heating, transfer the reactant into a 500mL pear-shaped separatory funnel, take the upper oil phase, wash it with warm water at 50°C for several times, and place the final oil phase solution in a vacuum oven for one day to remove n-hexane , ethanol and water to obtain colloidal iron oleate.

[0048] 2) Weigh 9.0g (10mmol) of the ferric oleate prepared above and dissolve it in 60mL of 1-octadecene (ODE). After the ferric oleate is completely dissolved, transfer the solution into a 250mL three-necked flask, and drop Add 3.3mL (10mmol) oleic acid, under magnetic stirring and nitrogen protection, first raise the temperature to 110°...

Embodiment 2

[0050] Take by weighing the prepared oil-soluble Fe of 120mg embodiment 1 3 o 4 Nanoparticles (MNPs-OA) were placed in a 100mL three-neck flask, ultrasonically dispersed with 20mL o-dichlorobenzene, and 20mL DMF solution containing 240mg citric acid monohydrate (CA) was added dropwise under ultrasonic, then sealed, and magnetically stirred at a certain speed , kept at 100° C. in an oil bath for 48 hours, after the reaction was completed, the solution was cooled to room temperature, washed several times by centrifugation with absolute ethanol, and the product was lyophilized into powder.

[0051] Wherein, the structural formula of citric acid monohydrate is as follows:

[0052]

[0053] Depend on Figure 4 b It can be seen that the surface of the prepared Fe modified by citric acid 3 o 4 Nanoparticles (MNPs-CA) were dispersed in the water phase, but not in the oil phase, indicating that the prepared Fe 3 o 4 Nanoparticles are hydrophilic. The citric acid-modified wate...

Embodiment 3

[0055] Take by weighing the prepared oil-soluble Fe of 120mg embodiment 1 3 o 4 Nanoparticles (MNPs-OA) were placed in a 100mL three-necked flask, ultrasonically dispersed with 20mL o-dichlorobenzene, and 20mL DMF solution dissolved in 240mg butanetetracarboxylic acid (BTCA) was added dropwise under ultrasonic, then sealed, and magnetically Stir and keep warm in an oil bath at 100°C for 48 hours. After the reaction is completed, the solution is cooled to room temperature, centrifuged and washed several times with absolute ethanol, and the product is lyophilized into powder.

[0056]Wherein, the structural formula of butane tetracarboxylic acid is as follows:

[0057]

[0058] Depend on Figure 4 c shows that the prepared surface is modified by butane tetracarboxylic acid Fe 3 o 4 Nanoparticles (MNPs-BTCA) were dispersed in the water phase, but not in the oil phase, indicating that the prepared Fe 3 o 4 Nanoparticles are hydrophilic. The butane tetracarboxylic acid mo...

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Abstract

The invention discloses Fe3O4 nano-particles with high dispersion stability in water phase, and a preparation method of the Fe3O4 nano-particles. The surface ligand of each Fe3O4 nano-particle is poly-carboxyl organic molecule with three or more carboxyl groups; the preparation method of the Fe3O4 nano-particles comprises the steps of: firstly, taking high boiling point organic solvent as solvent and oleic acid as the ligand; carrying out high-temperature thermal decomposition on iron oleate to obtain mono-dispersed oil-soluble Fe3O4 nano-particles; and then, adopting a method of ligand exchange, and using the poly-carboxyl organic molecules to replace the oleic acid ligands on the surfaces of the oil-soluble Fe3O4 nano-particles to obtain the water-soluble Fe3O4 nano-particles. The preparation method is convenient in operation process, low in requirement for equipment and low in price of the needed raw materials, and by-products are pollution-free. The water-soluble Fe3O4 nano-particles have better water system dispersion stability within the pH value range of 2-13, and a new economical and practical method is provided for preparing hydrophilic Fe3O4 nano-particles applied to the biological medicine field.

Description

technical field [0001] The present invention relates to a kind of Fe with high dispersion stability in water phase 3 o 4 Nanoparticles and preparation method thereof, especially relate to a kind of multi-carboxyl modified Fe with high dispersion stability in aqueous phase 3 o 4 Nanoparticles and methods for their preparation. Background technique [0002] In recent years, Fe 3 o 4 Magnetic nanoparticles (MNPs) are widely used in biological fields such as bioseparation, magnetic hyperthermia, targeted drug delivery, and magnetic resonance imaging (MRI) due to their unique magnetic responsiveness, superparamagnetism, and good biocompatibility. Applications. In the above-mentioned biological applications, magnetic nanoparticles must not only have excellent magnetic properties, uniform particle size and narrow particle size distribution, but also have good dispersion, stability and specific surface chemical properties in biological environments. . However, due to the nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08B82Y40/00
Inventor 窦红静蒋泽权孙康宋晟
Owner SHANGHAI JIAO TONG UNIV
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