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Determination method of coumarin components in Astragalus chinensis

A technology of coumarins and hydroxycoumarins, which is applied in the directions of measuring devices, material separation, and analysis of materials, can solve problems such as lack of scientific and standardized medication guidance, and achieve high accuracy, simple operation, and good repeatability. Effect

Inactive Publication Date: 2020-03-27
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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Problems solved by technology

Although the anti-tumor effect is remarkable, it mainly relies on folk prescriptions and lacks scientific and standardized medication guidance

Method used

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  • Determination method of coumarin components in Astragalus chinensis
  • Determination method of coumarin components in Astragalus chinensis
  • Determination method of coumarin components in Astragalus chinensis

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Embodiment 1

[0045] Simultaneous determination of the contents of erinnoside, 7-hydroxycoumarin, and 7-hydroxy-8-methoxycoumarin in the genus Asteraceae by HPLC:

[0046] 1. The materials, instruments and reagents used are as follows:

[0047] 1.1 The content of coumarin components was determined in 4 batches of powdered medicinal materials from Jinxiu Town, Tongmu Town, Sanjiao Township and Dazhang Township in Jinxiu Yao Autonomous County, Guangxi.

[0048] 1.2 Experimental Instruments

[0049] Agilent1206 high performance liquid chromatography with DAD detector (Agilent Technologies Co., Ltd., USA) AG-204 electronic analytical balance (METTLER TOLEDO); HH-S 6 Digital display constant temperature water bath (Jintan Medical Instrument Factory); MilliporeSimplicity-UV ultrapure water device (Millipore, USA).

[0050] 1.3 Reagent

[0051] Innoside reference substance (Shanghai Yuanye Biotechnology Co., Ltd., batch number R14M7F11135, with a content of 98%), 7-hydroxycoumarin (National Ins...

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Abstract

The invention discloses a determination method for the content of coumarin components in pileostegia tomentella. Content detection of the courmarin components is carried out by adopting an HPLC (High Performance Liquid Chromatography); the content detection is carried out on the courmarin components of skimmin, 7-hydroxy courmarin and 7-hydroxy-8-methoxy courmarin; adopted chromatographic conditions are as follows: a chromatographic column adopts C18 (5 mu m, 250*4.6 mm); the detection wavelength is 320 nm; mobile phases comprise a mobile phase A and a mobile phase B, the mobile phase A is prepared from acetonitrile, the mobile phase B is prepared from a phosphoric acid solution of which the concentration is 0.2 percent, and gradient elution is carried out; the column temperature is 25 DEG C; the flowing speed is 1.0 ml / min; the sample amount is 10 mu L. The determination method disclosed by the invention is simple in operation, high in accuracy degree and good in repeatability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a method for determining the content of coumarin components in the astragalus. Background technique [0002] Judging from the current development trend of anti-tumor drug research, a lot of research work has been done in this aspect of anti-tumor drugs at home and abroad, and certain results have been obtained. Some drugs with better anti-tumor properties have been found and developed. However, in general, there are not many drugs with high efficiency and less adverse reactions, which cannot meet the clinical needs of tumor patients. At the same time, drugs with specific effects for treating tumors have not yet been developed. Utilizing the existing medical research technology, increasing the screening of natural products with anti-tumor effects, and striving to develop anti-tumor drugs with high efficiency and low toxicity is not only the urgen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/34G01N30/74G01N30/86G01N30/06G01N30/14
CPCG01N30/02G01N30/06G01N30/14G01N30/34G01N30/74G01N30/86G01N30/8624G01N2030/146
Inventor 陆国寿卢文杰黄周锋谭晓黄建猷胡筱希刘吉成
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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