Methods, compounds, and compositions for the treatment of musculoskeletal diseases
By developing non-peptide compounds as Mas receptor agonists or mimetics of heptapeptide A(1-7), the problems of high cost and limited delivery methods of existing heptapeptide A(1-7) peptide analogs are solved. , achieving effective treatment of muscle atrophy and muscle dysfunction diseases, improving muscle strength and muscle regeneration ability.
Inactive Publication Date: 2017-08-18
UNIV OF SOUTHERN CALIFORNIA
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Problems solved by technology
[0010] Despite these apparent effects in these preclinical models, however, due to the high cost and limited delivery methods of A(1-7) peptides and related peptide analogs (which are usually limited to parenteral routes of administration, e.g. subcutaneous, intramuscular and intravenous), so their therapeutic potential is limited
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0207] Daily administration of the non-peptidic small molecule Mas agonist (“Mas agonist”) compound 7 by subcutaneous injection over 10 weeks in combination with angiotensin (1-7) (a literature shown to improve outcome in mdx mice of peptides).
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The invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy, neuromuscular disease, muscular dystrophy, muscular atrophy, drug-induced myopathy, and related disease, disorder or condition that causes a decrease in muscle strength, comprising the use of heterocyclic non-peptidic compounds that act as Mas agonists and / or mimics of angiotensin 1-7.
Description
[0001] related application [0002] This application claims the benefit of US Provisional Application No. 62 / 026,006, filed July 17, 2014, and US Provisional Application No. 62 / 053,035, filed September 19, 2014. The entire contents of both applications are incorporated herein by reference in their entirety. [0003] This application is also related to PCT application PCT / US14 / 30071 filed March 15, 2014, the entire contents of which are incorporated herein by reference in their entirety. technical field [0004] The present invention relates to methods, compounds and compositions for the treatment of musculoskeletal diseases or disorders, and related conditions, including muscular dystrophy, muscle wasting, muscle dysfunction and muscle damage, by the use of non-peptide compounds, wherein said non-peptide Compounds act as Mas receptor agonists and / or mimic the heptapeptide angiotensin (1-7). Background technique [0005] PCT application PCT / US14 / 30071, filed March 15, 2014,...
Claims
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IPC IPC(8): A61P21/00
CPCA61K31/496A61K31/506A61K31/5377A61K31/4439A61P21/00A61P21/02A61P21/04A61P43/00
Owner UNIV OF SOUTHERN CALIFORNIA
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