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A kind of preparation method of indapamide impurity

A technology of indapamide and impurities, applied in the field of chemical substance preparation, to achieve the effects of low production cost, high impurity purity, and low energy consumption

Active Publication Date: 2020-02-11
HEFEI HUAFANG PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, indapamide has the following adverse reactions: 1. Digestive system, diarrhea, loss of appetite, nausea, etc., occasionally dry mouth, nausea, constipation, etc.; 2. Cardiovascular system, orthostatic hypotension, Palpitations, arrhythmia, etc.; 3. Nervous system, rare headache, insomnia, occasional dizziness, paresthesia, etc.; 4. Metabolism, rare hyponatremia, hypokalemia, hypochloremic alkalosis; 5. Skin, rare Allergic reactions such as rash and itching

Method used

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  • A kind of preparation method of indapamide impurity
  • A kind of preparation method of indapamide impurity
  • A kind of preparation method of indapamide impurity

Examples

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Effect test

Embodiment 1

[0024] A method for preparing indapamide impurities, comprising the following steps: uniformly mixing tetrahydrofuran, indapamide, and cerium ammonium nitrate, stirring at room temperature for 1.5 hours, and purifying to obtain the indapamide impurities.

Embodiment 2

[0026] A method for preparing indapamide impurities, comprising the steps of: mixing 100ml of ethanol, 0.02mol of indapamide, 0.005mol of ferric sulfate, and 5ml of sulfuric acid aqueous solution with a mass fraction of 10wt%, stirring at room temperature for 2 hours, and recovering ethanol under reduced pressure Finally, the concentrated solution is obtained; dichloromethane is added to the concentrated solution to extract the dichloromethane phase, the dichloromethane phase is washed with water, dried, and the dichloromethane is recovered under reduced pressure to obtain a solid; the solid is recrystallized with isopropanol water to obtain Indapa Amine impurities.

Embodiment 3

[0028] A preparation method for indapamide impurity, comprising the steps of: mixing 100ml of dichloromethane, 0.01mol of indapamide, and 0.02mol of cerium ammonium nitrate, stirring at room temperature for 1.5h, filtering to take the filtrate, recovering and removing the dichloromethane A solid was obtained; the solid was recrystallized with acetone water to obtain the impurity of indapamide.

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Abstract

The invention discloses a method for preparing an indapamide impurity. The method comprises the following steps: uniformly mixing a first organic solvent, indapamide and an oxidizing agent, stirring at a room temperature for 1-2 hours, purifying, thereby obtaining the indapamide impurity. The method disclosed by the invention is low in energy consumption, low in production cost and simple in operation, and the prepared indapamide impurity is high in purity and high in yield.

Description

technical field [0001] The invention relates to the technical field of chemical substance preparation, in particular to a method for preparing indapamide impurities. Background technique [0002] Hypertension is a common and frequently-occurring disease, and it can also cause cardiovascular and cerebrovascular, kidney and other diseases. It is currently one of the diseases that cause the highest human mortality in the world. The use of diuretics to lower blood pressure in humans began in 1948. For a long time, thiazide diuretics have been one of the main forces of antihypertensive drugs, and they have clear curative effects no matter they are used alone or in combination with other antihypertensive drugs. The results of large-scale international clinical trials over the past few decades have further confirmed its position in antihypertensive therapy. Several European and American committees on the management of hypertension have recommended diuretics as the drug of choice f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/08
CPCC07D209/08
Inventor 何勇陈仕云高永好杨贤龙彭扶云吴宗好
Owner HEFEI HUAFANG PHARMA SCI & TECH